Authors Gaitzsch, J. ; Canton, I. ; Appelhans, D. ; Battaglia, G. ; Voit, B.
Title Cellular interactions with photo-cross-linked and pH-sensitive polymersomes: biocompatibility and uptake studies
Date 09.11.2012
Number 35583
Abstract Polymeric nanoparticles, specifically polymersomes, are at the leading edge of the rapidly developing field of nanotechnology. However, their use for biological applications is primarily limited by the biocompatibility of the components. Hence, optimization of polymersome synthesis protocols should carefully consider aspects of cellular toxicity. In this work, we investigate the viability of HDF and HeLa cells treated with photo-cross-linked and pH-sensitive polymersomes. We demonstrate how aspects of polymersome preparation conditions such as cross-linking density and UV irradiation time may affect their cytotoxic properties. Additionally, we also study the cellular uptake of our polymersomes into the cell types mentioned.
Publisher Biomacromolecules
Citation Biomacromolecules 13 (2012) 4188–4195
Tags drug-delivery gene delivery block length vesicles nanoparticles nanoreactor dna encapsulation permeability endocytosis

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