Authors Gaitzsch, J. ; Appelhans, D. ; Wang, L. ; Battaglia, G. ; Voit, B.
Title Synthetic bio-nanoreactor: Mechanical and chemical control of polymersome membrane permeability
Date 28.03.2012
Number 31769
Abstract pH-sensitive polymersomes have been stabilized by UV cross-linking after incorporation of an enzyme in a synthetic bionanoreactor without transmembrane proteins. This stabilization allows the reversible swelling and deswelling of the polymersomes upon changes in the pH value. The controlled reaction of the enclosed enzyme could be monitored selectively at pH 6, when the substrate could penetrate the membrane.
Publisher Angewandte Chemie - International Edition
Citation Angewandte Chemie - International Edition 51 (2012) 4448-4451
Tags bio-nanoreactors membranes polymersomes poration shear force vesicle permeability delivery

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