Authors Banerjee, S. ; Voit, B. ; Heinrich, G. ; Böhme, F.
Title A new versatile synthesis of 4-substituted diaminopyridine derivatives
Date 02.05.2012
Number 31702
Abstract A new convenient method for the synthesis of substituted 2,6-diacetamido pyridines has been developed. It starts from 4-hydroxypyridine and comprises the introduction of the amino groups by the Chichibabin reaction. After several protection and deprotection steps 2,6-diacetamido-4-hydroxy pyridine is obtained, which is regarded as a key compound for the synthesis of various substituted 2,6-diacetamido pyridines. It is shown that the free hydroxy group is susceptible for nucleophilic substitution. This provides an easy access to the introduction of different functional groups at 4-position of 2,6-diacetamido pyridine. The advantages over other procedures described in the literature are discussed.
Publisher Tetrahedron Letters
Citation Tetrahedron Letters 53 (2012) 2236-2238
Tags substituted diaminopyridine chichibabin reaction nucleophilic substitution heterocyclic compounds binding thiols

Back to list