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Authors
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Voit, B. ; Roßberg, C. ; Appelhans, D. ; Komber, H. ; Krahl, F. ; Arndt, K.-F. ; Lederer, A.
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Title
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Self-assembly of anionic core-shell architectures into ph-stable particles with defined dimensions as potential carrier systems
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Date
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18.03.2011
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Abstract
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We demonstrate the formation and characterization of pH- and buffer-stable anionic particles as potential carrier systems. The formation of those particles is provided by the self-assembly of anionic dendritic core-shell architectures which consist of hyperbranched poly(ethyleneimine) (PEI) as core and oligomeric/polymeric glutamate chains, attached on the PEI surface, as anionic shell. The self-assembly study by DLS exhibits the formation of very stable particles between 0.4 to 2 µm depending on the pH used during self-assembly.<br />Thus, the self-assembly process of the dendritic core-shell architectures gives us the chance to realize particles with heterogeneous surface composition using different (bio-active) functionalized surfaces of the core-shell architectures for future studies in the (bio-)medical field.
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Journal
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Polymer Preprints 52 (2011) 598
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DOI
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http://abstracts.acs.org/chem/241nm/program/view.php?obj_id=65457
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