Authors Appelhans, D. ; Zhong, Y. ; Komber, H. ; Friedel, P. ; Oertel, U. ; Scheler, U. ; Morgner, N. ; Kuckling, D. ; Richter, S. ; Seidel, J. ; Brutschy, B. ; Voit, B.
Title Oligosaccharide-modified poly(propyleneimine) dendrimers: Synthesis, structure determination, and Cu(II) complexationa
Date 26.04.2007
Number 14535
Abstract The multiple application of reductive amination on primary amino groups of first and second generation poly(propyleneimine) dendrimers is used as a one-pot approach to introduce twice the amount of the oligosaccharide units as surface groups, compared to initially present amino groups in the first and second generation dendrimers. This was proven by 1H NMR, MALDI-TOF-MS, and LILBID-MS analysis. The size of these dendrimers was determined by the hydrodynamic radius using pulsed field gradient NMR and dynamic light scattering. Molecular modeling confirmed the presence of dense-shell dendrimers. These dendrimers exhibit a generation dependent CuII/dendrimer ratio in an aqueous environment, highlighting these materials as possible metal-carrier systems with a well-defined oligosaccharide protection shell for application in a biological environment.
Publisher Macromolecular Bioscience
Citation Macromolecular Bioscience 7 (2007) 373-383
Tags dendrimers metal complexation metal-intradendrimer complexes oligosaccharides water-soluble polymers encapsulated metal nanoparticles imine) dendrimers mass-spectrometry self-diffusion polypeptides molecules ligands binding system field

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