Authors Stephan, H. ; Geipel, G. ; Appelhans, D. ; Bernhard, G. ; Tabuani, D. ; Komber, H. ; Voit, B.
Title Pegylation of 1,4,8,11-tetraazacyclotetradecane (cyclam) and its Cu(II) complexation
Date 20.04.2005
Number 13119
Abstract Two novel star-like cyclam derivatives appended with four amino groups and four PEG-arms have been synthesised. The complex formation of cyclam and the two cyclam derivatives with Cu(II) has been studied by UV–vis and time-resolved laser-induced fluorescence (TRLFS) measurements outlining 1:1 complexes between cyclam ligands and Cu(II). By TRLFS measurements a quench effect of the Cu(II) on the fluorescence of the ligand was also found to determine the complex formation between Cu(II) and the ligands.
Publisher Tetrahedron Letters
Citation Tetrahedron Letters 46 (2005) 3209-3212
Tags cyclam synthesis complex formation fluorescence metal-complexing nanoparticles macrocycle interaction kinetic data ligands dendrimers recognition derivatives agents core radiopharmaceuticals

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