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Paper "Coagulation matters: ATIII-enriched biomolecular corona enhances the hemocompatibility of PEG nanoparticles" published
The new paper "Coagulation Matters: ATIII-Enriched Biomolecular Corona Enhances the Hemocompatibility of PEG Nanoparticles" by Vaidehi Londhe, Manfred F. Maitz, Triantafyllos Chavakis, Carsten Werner, Alessia C. G. Weiss, and Quinn A. Besford introduces an innovative approach to engineer the biological identity of nanoparticles. This research highlights how poly(ethylene glycol) (PEG) nanoparticles, often chosen for stealthy and low-fouling characteristics, can be enriched with a functional corona of heparin-antithrombin III (HEP-ATIII) complexes. These engineered nanoparticles maintain inherent stealth and achieve a 4-fold reduction in coagulation activation, in comparison to native PEG nanoparticles. This enhanced hemocompatibility comes without inducing adverse inflammatory reactions or disrupting the nanoparticles' inherent stealth and low-fouling characteristics. This work highlights another dimension to nanoparticle design for hemocompatibility, aside from stealth and low-fouling: coagulation matters! These important findings highlight biomolecular corona the potential of exerting control over protein corona interactions towards developing hemocompatible therapeutic nanomaterials. The paper was published in Advanced Healthcare Materials.
16.07.2025