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A biphasic in vitro model of early breast cancer bone metastasis published in Advanced Science
Jana Sievers-Liebschner and colleagues designed mineralized cryogel/hydrogel constructs that mimic various components of the bone microenvironment to advance the in vitro investigation of early breast cancer bone metastasis. Microscopic monitoring of spatiotemporal cancer cell distribution and cellular gene expression showed that deposited bone-like mineral plays a crucial role in modulating the response of cancer cells to biomolecular signals that control metastatic bone colonization. The reported methodology – developed in collaboration with Claudia Fischbach (Cornell University, Ithaca, New York, USA) and Peter Fratzl (Max Planck Institute of Colloids and Interfaces, Potsdam, Germany) - may not only provide further mechanistic insights into early bone metastasis, but also facilitate the investigation of metastasis-inhibiting therapies.
Publication: Sievers-Liebschner et al. Mineralized Cryogel/Hydrogel Constructs to Recapitulate Early Breast Cancer Bone Metastasis In Vitro. Advanced Science (2025).
30.01.2026