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Publication on the blood response to different doses of silk nanoparticles
The publication “Blood compatibility of silk nanoparticles: impact of size and dose” presents a collaboration between Manfred Maitz at the IPF Dresden and Philipp Seib at the University of Strathclyde in Glasgow (now at the University of Jena). It shows that the activation of the coagulation and complement cascades in blood by silk nanoparticles depends mainly on particle mass concentration, whereas leukocyte activation scales primarily with particle count. These findings give guidelines for the design of silk nanoparticles for nanomedicine applications. The study is published in the International Journal of Pharmaceutics.
Publication: Manfred F. Maitz, John D. Totten, Alessia C.G. Weiss, Quinn A. Besford, Carsten Werner, F. Philipp Seib. Blood compatibility of silk nanoparticles: impact of size and dose. International Journal of Pharmaceutics (2025).
05.01.2026