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Dr. Petra Welzel

Institute of Biofunctional Polymer Materials
+49 351 4658 584 +49 351 4658 533

Fields of Work

development of cell-instructive macroporous and multiphasic hydrogel materials for new therapeutic concepts as well as for advanced tissue and disease models;
adsorption of proteins at solid/liquid interfaces

 

 

Publications

  • Welzel, P. ; Friedrichs, J. ; Grimmer, M. ; Vogler, S. ; Freudenberg, U. ; Werner, C. Cryogel micromechanics unraveled by atomic force microscopy-based nanoindentation more Advanced Healthcare Materials 3 (2014) 1849-1853
  • König, U. ; Lode, A. ; Welzel, P. ; Ueda, Y. ; Knaack, S. ; Henß, A. ; Hauswald, A. ; Gelinsky, M. Heparinization of a biomimetic bone matrix: integration of heparin during matrix synthesis versus adsorption of heparin during matrix synthesis versus adsorptive post surface modification more Journal of Materials Science : Materials in Medicine 25 (2014) 607-621
  • Joly, P. ; Duda, G. N. ; Schöne, M. ; Welzel, P. ; Freudenberg, U. ; Werner, C. ; Petersen, A. Geometry-driven cell organization determines tissue growths in scaffold pores: Consequences for fibronectin organization more PLoS ONE 8 (2013) e73545
  • Zieris, A. ; Werner, C. ; Prokoph, S. ; Levental, K. ; Welzel, P. ; Chwalek, K. ; Schneider, K. ; Freudenberg, U. Sustainable growth factor delivery through affinity-based adsorption to star PEG-heparin hydrogels more American Chemical Society 1120 (2012) Chapter 24, 525-541
  • Welzel, P. ; Grimmer, M. ; Renneberg, C. ; Naujox, L. ; Zschoche, St. ; Freudenberg, U. ; Werner, C. Macroporous starPEG-heparin cryogels more Biomacromolecules 13 (2012) 2349-2358
  • Freudenberg, U.; Sommer, J.-U.; Levental, K.; Welzel, P; Zieris, A.; Chwalek, K.; Schneider, K.; Prokoph, S.; Prewitz, M.; Dockhorn, R.; Werner, C. Using Mean Field Theory to Guide Biofunctional Materials Design more Advanced Functional Materials 22 (2012) 1391-1398
  • Polikarpov, N. ; Appelhans, D. ; Welzel, P. ; Kaufmann, A. ; Dhanapal, P. ; Bellmann, C. ; Voit, B. Tailoring uptake and release of ATP by dendritic glycopolymer/PNIPAAm hydrogel hybrids: first approaches towards multicompartment release systems more New Journal of Chemistry 36 (2012) 438-451
  • Zieris, A. ; Chwalek, K. ; Prokoph, S. ; Levental, K. ; Welzel, P. ; Freudenberg, U. ; Werner, C. Dual independent delivery of pro-angiogenic growth factors from starPEG-heparin hydrogels more Journal of Controlled Release 156 (2011) 28-36
  • Welzel, P. ; Prokoph, S. ; Zieris, A. ; Grimmer, M. ; Zschoche, St. ; Freudenberg, U. ; Werner, C. Modulating biofunctional starPEG heparin hydrogels by varying size and ratio of the constituents more Polymers [Open Access] 3 (2011) 602-620
  • Sommer, J.-U. ; Dockhorn, R. ; Welzel, P. ; Freudenberg, U. ; Werner, C. Swelling equilibrium of a binary polymer gel more Macromolecules 44 (2011) 981–986
  • Zieris, A. ; Prokoph, S. ; Levental, K. ; Welzel, P. ; Grimmer, M. ; Freudenberg, U. ; Werner, C. FGF-2 and VEGF functionalization of starPEG-heparin hydrogels to modulate biomolecular and physical cues of angiogenesis more Biomaterials 31 (2010) 7985-7994
  • Zieris, A. ; Prokoph, S. ; Welzel, P. ; Grimmer, M. ; Levental, K. ; Panyanuwat, W. ; Freudenberg, U. ; Werner, C. Analytical approaches to uptake and release of hydrogel-associated FGF-2 more Journal of Materials Science : Materials in Medicine 21 (2010) 915-923
  • Welzel, P. ; Nitschke, M. ; Freudenberg, U. ; Zieris, A. ; Götze, T. ; Valtink, M. ; Engelmann, K. ; Werner, C. : Polymer Hydrogels to Enable New Medical Therapies more Springer 6 (2009) 249-266
  • Freudenberg, U. ; Hermann, A. ; Welzel, P. ; Stirl, K. ; Schwarz, S. ; Grimmer, M. ; Zieris, A. ; Panyanuwat, W. ; Zschoche, St. ; Meinhold, D. ; Storch, A. ; Werner, C. A starPEG-heparin hydrogel platform to aid cell replacement therapies for neurodegenerative diseases more Biomaterials 30 (2009) 5049-5060
  • Gelinsky, M. ; Welzel, P. ; Simon, P. ; Bernhardt, A. ; König, U. Porous three-dimensional scaffolds made of mineralised collagen: preparation and properties of a biomimetic nanocomposite material for tissue engineering of bone more Chemical Engineering Journal 137 (2008) 84-96
  • Freudenberg, U. ; Behrens, S.-H. ; Welzel, P. ; Müller, M. ; Grimmer, M. ; Salchert, K. ; Taeger, T. ; Schmidt, K. ; Pompe, W. ; Werner, C. Electrostatic interactions modulate the conformation of collagen I more Biophysical Journal 92 (2007) 2108-2119
  • Klose, T. ; Welzel, P. ; Werner, C. Protein adsorption from flowing solutions on pure and maleic acid copolymer modified glass particles more Colloids and Surfaces B: Biointerfaces 51 (2006) 1-9
  • Brandes, N. ; Welzel, P. ; Werner, C. ; Kroh, L.W. Adsorption-induced conformational changes of proteins onto ceramic particles: Differential scanning calorimetry and FTIR analysis more Journal of Colloid and Interface Science 299 (2006) 56-69
  • Schweiß, R. ; Welzel, P. ; Knoll, W. ; Werner, C. Assembly modulates dissociation: electrokinetic experiments reveal peculiarities of the charge formation at monolayer films more Chemical Communications (2005) 256-258
  • Schweiß, R. ; Pleul, D.Pleul ; Simon, F. ; Janke, A. ; Welzel, P. ; Voit, B. ; Knoll, W. ; Werner, C. Electrokinetic Potentials of Binary Self-Assembled Monolayers on Gold: Acid-Base Reactions and Double Layer Structure more Journal of Physical Chemistry / B 108 (2004) 2910-2917
  • Schönhoff, M. ; Larsson, A. ; Welzel, P. ; Kuckling, D. Thermoreversible Polymers Adsorbed to Colloidal Silica: A 1H NMR and DSC Study of the Phase Transition in Confined Geometry more Journal of Physical Chemistry / B 106 (2002) 7800-7808
  • Welzel, P. ; Rauwolf, C. ; Yudin, A. ; Grundke, K. Influence of Aqueous Electrolytes on the Wetting Behavior of Hydrophobic Solid Polymers - Low-Rate Dynamic Liquid/Fluid Contact Angle Measurements Using Axisymmetric Drop Shape Analysis more Journal of Colloid and Interface Science 252 (2002) 101-108
  • Welzel, P. Investigation of adsorption-induced structural changes of proteins at solid/liquid interfaces by differential scanning calorimetry more Thermochimica Acta 382 (2002) 175-188
  • Schweiß, R. ; Welzel, P. ; Werner, C. ; Knoll, W. Interfacial charge of organic thin films characterized by streaming potential and streaming current measurements more Colloids and Surfaces A: Physicochemical and Engineering Aspects 195 (2001) 97-102
  • Schweiß, R. ; Welzel, P. ; Werner, C. ; Knoll, W. Dissociation of surface functional groups and preferential adsorption of ions on self assembled monolayers in aqueous electrolyte solutions assessed by streaming potential and streaming current measurements more Langmuir 17 (2001) 4304-4311