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INSTITUTE OF BIOFUNCTIONAL POLYMER MATERIALS

Prof. Dr. Horst von Recum
Case Western Reserve University, Cleveland, Ohio, USA
Title: "Refillable materials for recurrent or chronic drug delivery"
September, 16, 2019, 10:30, Seminar Room Max Bergmann Center
Dr. Amedea Seabra
Universidade Federal do ABC, Santo Andre, Brazil
Title: "Nitric oxide releasing biomaterials for biomedical applications"
September, 16, 2019, 2019, 14:00, Conference Room
The article "Quick-gelling inks allow high-resolution bioprinting", describing our recent Biofabrication paper (10.1088/1758-5090/ab2aa1), is now live on Physics World; .
Researchers of the Leibniz-Institut für Polymerforschung Dresden e.V. received the MaterialVital Award 2019 of the Federal Ministry of Science and Education (BMBF) within the ProMatLeben initiative.
Dr. Passant Atallah, Dr. Lucas Schirmer, Dr. Uwe Freudenberg and Prof. Dr. Carsten Werner from the Leibniz Institute of Polymer Research Dresden e.V. (IPF) received the award "Best Development in the Field of Polymers for the Health Sector - Largest Innovation Potential" of the ProMatLeben initiative of the Federal Ministry of Education and Research (BMBF) for the development of novel hydrogel wound dressings to treat chronic skin wounds. In Germany alone, there are currently more than 900,000 patients with chronic wound healing disorders who often also suffer from diabetes or cardiovascular diseases.
In cooperation with partners in the DFG Collaborative Research Centre Transregio 67 (Dr. Sandra Franz and Prof. Jan-Christoph Simon, University of Leipzig), the research team was able to develop polymer networks from derivatives of the glycosaminoglycan heparin and branched poly(ethylene glycol), which can absorb inflammation-promoting signal molecules from the wound like a "molecular sponge". The design of the polymer networks advantageously allows for retaining signal molecules that promote wound healing. Since the hydrogel wound dressing does not release bioactive substances, the new technology is expected to become quickly approved and translated into clinical application. For this purpose, a hydrogel-coated textile wound contact dressing has now been developed and successfully tested in a large animal model. The team of prizewinners is currently preparing the spin-off of a company.
Carsten Werner participates in the "Nanolithography of Biointerfaces Faraday Discussion" (03.-05. July 2019) at the Royal Society of Chemistry in London, UK,
presenting our recent progress on charge-tuning of glycosaminoglycan-based hydrogels for cytokine sequestration (co-authors Passant Atallah, Yanuar Limasale and Uwe Freudenberg).
Dr. Toshihisa Osaki
Kanagawa Institute of Industrial Science and Technology, Kanagawa, Japan
Title: "Artificial Cell Membrane Platforms for Drug Discovery and Super Sensors"
June, 28, 2019, 10:30, Seminar Room Max Bergmann Center
15 million people worldwide suffer a stroke each year. To date, treatment options that reduce the consequential damage after a stroke are limited. A promising new approach targets the repair of the vascular system which entails the regeneration of brain tissue and leads to an amelioration of the corresponding body function. In this study, antibodies against Nogo-A, a growth-inhibiting molecule for nerve fibers as well as vessels, were applied to mice after a stroke. The blood vessels in these mice showed improved regenerative capacity, and they recovered affected motor skills better than those of the mice in the control group. To eliminate the impact of signaling from the surrounding tissue observed in in vivo studies, capillary network formation was furthermore investigated in a three dimensional culture of human umbilical vein vascular endothelial cells (HUVECs) in defined glycosaminglycan-starPEG-based hydrogels confirming the in vivo results. Antibodies against Nogo-A are already being used in a phase II study to treat patients with spinal cord injuries and could soon significantly benefit stroke patients as well.

Press Release Universität Zürich

Publication:
Ruslan Rust et al. Nogo-A Targeted Therapy Promotes Vascular Repair and Functional Recovery Following Stroke. PNAS. June 24, 2019. DOI: 10.1073/pnas.1905309116
Manfred Maitz (IBP) has been appointed as Guest-Professor (2019-2023)
at the "Southwest Jiaotong University in Chengdu", China.

Congratulations!
The German Research Foundation (DFG) will support Alla Synytska (Polymer Interfaces, IPF) and Carsten Werner over the next three years to work on a new project titled „Amphiphilic Fouling-Resistant Surfaces Based on Janus particles”.

Alla Synytska, Jens Friedrichs and team will jointly explore a new, scalable design strategy for amphiphilic surfaces with controlled fouling resistance relying polymer-functionalized colloidal particles as surface-immobilized building blocks. The ability of the developed surfaces to inhibit adhesion of different bacterial species will be tested using high throughput bulk- as well as single cell-assays. The combination of these methods is expected to gain mechanistic insight in the anti-adhesive capabilites of amphiphilic surfaces.

Awesome!
Ralf Zimmermann presents our recent findings on "Spatio-temporal morphogen gradients to direct cell-fate decisions in glycosaminoglycan-based hydrogels" at the "13th International Symposium on Electrokinetics" (12.-14. June 2019) at the Massachusetts Institute of Technology, Cambridge, MA, USA.

ELKIN is a conference series for the discussion of new advances in research on electrokinetic phenomena and related topics. The meeting is held every two years at different locations worldwide (the previous conference took place at the IPF in 2017).

The participants of ELKIN 2019 will commemorate Johannes Lyklema (1930-2017), the founder and long term chairman of the "International Advisory Board" of the conference series, with a dedicated lecture given by Jerome Duval.
Carsten Werner and Uwe Freudenberg have been invited to present at the

"TERMIS European Chapter Meeting 0019 - Tissue Engineering Therapies: From Concept to Clinical Translation & Commercialisation"

(27.-31. May 2019) in Rhodes, Greece.

TERMIS is the most prominent organisation in the field of tissue engineering and regenerative medicine globally.