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Authors
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Simon, J.-C. ; Werner, C.
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Title
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12 years more than just skin and bones: the CRC Transregio 67
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Date
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31.12.2021
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Number
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59929
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Abstract
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In 2009, the German Research Foundation (DFG) established the collaborative research center (CRC) TRR67 “Functional biomaterials for controlling healing processes in bone and skin tissue – from material science to clinical application” (https://research.uni-leipzig.de/trr67/) as a joint effort of Leipzig University and Technische Universität Dresden with partners from Jena and the Technische Universität Berlin.<br />The demographic trends in Germany and other industrialized nations result in a considerable increase in patients with bone defects and chronic wounds. This requires the development of novel functional biomaterials, which improve bone and skin regeneration in an aging, multimorbid population. New knowledge about the role of the extracellular matrix (ECM) for the regeneration of tissues opens up new opportunities for the design of innovative biomaterials. In particular, the structure and composition of ECM significantly influences cellular differentiation and function and the healing of tissues. Hence, the aim of the TRR 67 was to develop and investigate novel functional biomaterials based on naturally occurring and chemically modified, artificial ECM. Essential functional components of these materials are glycosaminoglycan (GAG) derivatives and proteoglycan analogs in combination with structural proteins or synthetic carrier components
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Publisher
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Biological Chemistry
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Wikidata
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Citation
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Biological Chemistry 402 (2021) 1269-1270
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DOI
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https://doi.org/10.1515/HSZ-2021-0353
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