|
Authors
|
Ionov, L. ; Synytska, A. ; Diez, S.
|
|
Title
|
Protein-resistant polymer coatings based on surface-adsorbed poly(aminoethyl methacrylate)/poly(ethylene glycol) copolymers
|
|
Date
|
21.01.2010
|
|
Number
|
21386
|
|
Abstract
|
We report on the protein-resistant properties of glass substrates coated with novel copolymers of 2-aminoethyl methacrylate hydrochloride and poly(ethylene glycol) methyl ether methacrylate (AEM-PEG). In comparison to currently available protein-blocking polymer systems, such as poly-l-lysine-poly(ethylene glycol), silane-based poly(ethylene glycol), and poly(ethylene glycol) brushes prepared by surface-initiated polymerization, the proposed AEM-PEG offers the combined advantages of low cost, simplicity of use, and applicability in aqueous solutions. We demonstrate the capability of AEM-PEG to block the surface binding of globular proteins (tubulin), their assemblies (microtubules), and functional motor proteins (kinesin-1). Moreover, we demonstrate the applicability of AEM-PEG for surface patterning of proteins in microfluidic devices.
|
|
Publisher
|
Biomacromolecules
|
|
Wikidata
|
|
|
Citation
|
Biomacromolecules 11 (2010) 233-237
|
|
DOI
|
https://doi.org/10.1021/bm901082y
|
|
Tags
|
keywords plus: metal-oxide surfaces poly(ethylene glycol) block-copolymers adsorption kinesin layers density gold
|
