Authors Valle, J. ; Burgui, S. ; Langheinrich, D. ; Gil, C. ; Solano, C. ; Toledo-Arana, A. ; Helbig, R. ; Lasagni, A. ; Lasa, I.
Title Evaluation of surface microtopography engineered by direct laser interference for bacterial anti-biofoulinga
Date 01.08.2015
Number 46845
Abstract Modification of the biomaterial surface topography is a promising strategy to prevent bacterial adhesion and biofilm formation. In this study, we use direct laser interference patterning (DLIP) to modify polystyrene surface topography at sub-micrometer scale. The results revealed that three-dimensional micrometer structures have a profound impact on bacterial adhesion. Thus, line- and pillar-like patterns enhanced S. aureus adhesion, whereas complex lamella microtopography reduced S. aureus adhesion in static and continuous flow culture conditions. Interestingly, lamella-like textured surfaces retained the capacity to inhibit S. aureus adhesion both when the surface is coated with human serum proteins and when the material is implanted subcutaneously in a foreign-body associated infection model.
Publisher Macromolecular Bioscience
Citation Macromolecular Bioscience 15 (2015) 1060-1069
Tags adhesion biofilm biomaterial-associated infection direct laser interference patterning staphylococcus aureus fibronectin-binding proteins atomic-force microscope staphylococcus-aureus biofilm formation pseudomonas-aeruginosa adhesion attachment topography

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