Authors
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Shadabfar, M. ; Abdouss, M. ; Khonakdar, H. A.
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Title
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Synthesis, characterization, and evaluation of a magnetic molecular imprinted polymer for 5-fluorouracil as an intelligent drug delivery system for breast cancer treatment
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Date
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07.07.2020
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Number
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58684
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Abstract
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Magnetic carriers-based molecular imprinting has become one of the mostinteresting phenomena in the drug delivery field. In this study, we endeavor todevise an effective magnetic drug carrier via imprinting technology for 5-fluo-rouracil and investigate its anticancer activity toward breast cancer treatment. Inthis case, methacrylic acid and trimethylolpropane triacrylate were chosen forimprinting 5-fluorouracil on the magnetic fluorescent core. With this aim, flu-orescein isothiocyanate was utilized as a fluorescent agent. FT-IR, EDX, XRD,VSM, FESEM, TEM, and BET analysis were used to characterize the synthesizedcarrier. According to adsorption studies, the adsorption of 5-fluorouracil wasfollowed by Freundlich isotherm (QMAX: 121.6 mg/g) in a fast second-orderkinetic model (6 min) in our proposed carrier. Afterward, based on the releasestudies the Higuchi dynamic model was suggested for leaching of 5-fluorouracilfrom the carrier. Eventually, the cytotoxicity effect of the projected carrier onMCF-10 and MCF-7 cell lines was investigated. In this case, the magnetic carrierhas shown 61% cytotoxicity on cancer cells which were about 25 times greaterthan the pure drug, but it had no significant effect on normal cells. In all steps,the non-imprinted carrier was investigated as a comparison. This study hasshown that our proposed magnetic nanocarrier can effectively be utilized inbreast cancer treatment.
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Publisher
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Journal of Materials Science
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Wikidata
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Citation
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Journal of Materials Science 55 (2020) 12287-12304
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DOI
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https://doi.org/10.1007/S10853-020-04887-X
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Tags
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