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Authors
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Deng, Y.; Debbeler, J.; Träger, A.; Gaitzsch, J.
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Title
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Degradable nanocarriers capable of gene delivery derived from pH-responsive polyester: RROP copolymerization between cyclic ketene acetals
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Date
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01.01.2026
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Number
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0
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Abstract
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The ability to combine biodegradability with responsive units by radical ring-opening polymerization (RROP) is the ideal setup for a modern drug delivery system. Since the required polymers were recently unlocked by RROP copolymerization between different cyclic ketene acetals (CKAs), we herein prepared a series of polyester copolymers derived from an amine-bearing CKA 6-(iso-propyl)-2-methylene-1,3,6-dioxazocane (iPr-MAC) and 2-methylene-1,3,6-trioxocane (MTC). Functional nanoparticles with tunable sizes and extremely narrow size distributions could be achieved from these copolymers. Comprehensive studies showed that the resulting nanoparticles exhibited tuneable pH-transition points from 6.3 to 7.1 as the iPr-MAC content increased from 10 to 40 mol%, enabling precise pH-triggered control release at varying pH levels. Furthermore, this work demonstrates the potential of these pH-sensitive polyesters as an alternative to traditional polycations, exploring their biocompatibility and gene delivery capability, which suggests a new application prospect for CKA-derived functional polyesters.
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Publisher
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Wiley
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Wikidata
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Citation
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Macromolecular Rapid Communications 47 (2026) e00722
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DOI
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https://doi.org/10.1002/marc.202500722
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Tags
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