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Authors
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Heller, C.; Rosenberger, C.; Abdelgawad, H.; Basiewicz, T. M.; Lehmann, S.; Schmid, J.; Schubert, U.; Welzel, P. B.; Werner, C.; Bornstein, S. R.; Ludwig, B.
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Title
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An immunoisolating macroencapsulation device for pancreatic islets with microarranged islets, oxygen-producing scaffold and bioactive membrane improving islet survival and function
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Date
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01.10.2025
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Number
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0
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Abstract
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Type 1 diabetes (T1D) is a chronic autoimmune disorder characterized by the destruction of insulin-producing pancreatic beta cells, requiring lifelong treatment. Macroencapsulation of pancreatic islets - whether of xenogeneic origin or stem cell-derived - offers a promising therapeutic approach for T1D by protecting transplanted cells from immune rejection while maintaining their viability and function. However, insufficient oxygen (hypoxia) and suboptimal biocompatibility remain significant challenges in closed encapsulation systems, restricting graft survival and overall transplantation success. This study proposes a modular encapsulation device design consisting of a microarrangement module, an oxygen-producing scaffold and a bioactive immunoisolating membrane. This strategy aims to improve islet oxygenation and implant engraftment to advance the long-term efficacy of cell-based T1D therapies.
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Publisher
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Lippincott Williams & Wilkins
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Wikidata
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Citation
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Transplantation 109 (2025) S19
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DOI
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https://doi.org/10.1097/01.tp.0001170416.92819.f9
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Tags
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