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Authors
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Qiao, X.; Chen, H.; Schurig, A.; Wang, X.; Sun, Y.; Tobler, M.; Boye, S.; Castiglione, K.; Appelhans, D.; Huang, X.
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Title
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Spatio-temporal processes of diffusion-controlled communication in hierarchical multi-compartments
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Date
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17.04.2025
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Number
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0
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Abstract
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Exploring the synergy of feedback behavior and molecular communication between micro- and nanocompartments is of great implication for the development of advanced hierarchical living-like materials. Non-covalent interactions are the driving forces for dynamic and temporal events in biomimetic structures. Herein, pH-responsive hierarchical multicompartments (HMC) are constructed via hydrophobic-hydrophobic interactions between azobenzene units and phospholipid layers through the integration of two distinct structural units: phospholipid-membranized coacervates (Coa@DMPC) and azobenzene-functionalized polymersomes (Azo-Psomes). This enables to study spatio-temporal signal pathways for biomimetic pH homeostasis and the triggering of feedback-controlled peroxidase-like behavior of Azo-Psomes within HMC. Compared with undocking systems, the information transmission process within HMC shows a high efficiency. Besides the continuous addition of nutrients, the synchronization of two different biomimetic reactions in HMC requires the spatial loading of glucose oxidase and L-phenylalanine ammonia lyase in coacervates and of L-phenylalanine or beta-cyclodextrin/hemin complexes in Azo-Psomes. Azo-Psomes exhibit pH-responsive feedback-controlled behavior. The pH-responsive membrane of Azo-Psomes is responsible for the spatio-temporal peroxidase-like activity of lumen-integrated beta-cyclodextrin/hemin complexes in Azo-Psomes. Finally, this strategy provides a new approach to constructing more complex biomimetic systems by interconnecting at least two membrane-containing compartments to further explore the synergistic mechanisms and feedback behaviors among artificial cell communities.
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Publisher
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Wiley
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Wikidata
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Citation
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Angewandte Chemie - International Edition 64 (2025) e202424133
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DOI
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https://doi.org/10.1002/anie.202424133
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