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Dr. Andrea Meinhardt

Institute of Biofunctional Polymer Materials
+49 351 4658 1222 +49 351 4658 533

Personal data

05/2017 – Senior Scientist at Leibniz Institut für Polymerforschung Dresden e.V.
08/2014 – 04/2017 Scientific Coordinator at CRTD, TU Dresden, Germany
07/2007 – 08/2014 Postdoctoral fellow, TU Dresden, Germany, group of Prof. E. M. Tanaka
Topic: 3D reconstitution of the neural tube from mESCs
05/2002 – 06/2007 Postdoctoral fellow, CHUV Lausanne, Switzerland, group of Prof. Dr. med. G. Vassalli
Topics: Label-retaining cells in the adult mouse heart/Use of genetically engineered dendritic cells for heart transplantation
08/2001 – 01/2002 Postdoctoral fellow, University of Cologne, Germany, Institute of Biochemistry, group of Prof. Dr. rer. nat. R. Krämer
Topic: Glutamate transport in Corynebacterium glutamicum
07/2001 Scientific stay in Prague, Czech Republic, to continue the studies about the mitochondrial phosphate carrier from Saccharomyces cerevisiae
06/2001 PhD in Chemistry, University of Cologne, Germany, Institute of Biochemistry, group of Prof. Dr. rer. nat. R. Krämer
Topic: Investigation on structure and function of the mitochondrial phosphate carrier from Saccharomyces cerevisiae

Fields of work

  • Guiding early developmental processes in vitro by cell-instructive multi- and monophasic hydrogel materials
  • Neural tube organoid formation from human induced pluripotent stem cells in defined glycosaminoglycan-based hydrogel microenvironments
  • Material-based approaches to uncover mechanisms of stem cell fate regulation

 

 

Publications

Ishihara K, Ranga A, Lutolf MP, Tanaka EM*, Meinhardt A*
Reconstitution of a Patterned Neural Tube from Single Mouse Embryonic Stem Cells.
Methods Mol Biol. 2017;1597:43-55. doi:10.1007/978-1-4939-6949-4_4.
*Co-corresponding authorship

Ranga A, Girgin M, Meinhardt A, Eberle D, Caiazzo M, Tanaka EM, Lutolf MP.
Neural tube morphogenesis in synthetic 3D microenvironments.
Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):E6831-E6839.

Meinhardt A, Eberle D, Tazaki A, Ranga A, Niesche M, Wilsch-Bräuninger M, Stec A, Schackert G, Lutolf M, Tanaka EM.
3D reconstitution of the patterned neural tube from embryonic stem cells.
Stem Cell Reports. 2014 Dec 9;3(6):987-99. doi: 10.1016/j.stemcr.2014.09.020

Zhu Y, Carido M, Meinhardt A, Kurth T, Karl MO, Ader M, Tanaka EM.
Three-dimensional neuroepithelial culture from human embryonic stem cells and its use for quantitative conversion to retinal pigment epithelium.
PLoS One. 2013;8(1):e54552. doi: 10.1371/journal.pone.0054552

Meinhardt A, Spicher A, Roehrich ME, Glauche I, Vogt P, Vassalli G.
Immunohistochemical and flow cytometric analysis of long-term label-retaining cells in the adult heart.
Stem Cells Dev. 2011 Feb;20(2):211-22. doi: 10.1089/scd.2009.0203

Grisel P, Meinhardt A, Lehr HA, Kappenberger L, Barrandon Y, Vassalli G.
The MRL mouse repairs both cryogenic and ischemic myocardial infarcts with scar.
Cardiovasc Pathol. 2008 Jan-Feb;17(1):14-22

Li J*, Meinhardt A*, Roehrich ME, Golshayan D, Dudler J, Pagnotta M, Trucco M, Vassalli G.
Indoleamine 2,3-dioxygenase gene transfer prolongs cardiac allograft survival.
Am J Physiol Heart Circ Physiol. 2007 Dec;293(6):H3415-23.
*Co-first authorship

Trötschel C, Kandirali S, Diaz-Achirica P, Meinhardt A, Morbach S, Krämer R, Burkovski A.
GltS, the sodium-coupled L-glutamate uptake system of Corynebacterium glutamicum: identification of the corresponding gene and impact on L-glutamate production.
Appl Microbiol Biotechnol. 2003 Feb;60(6):738-42

Engstová H, Zácková M, Růzicka M, Meinhardt A, Hanus J, Krämer R, Jezek P.
Natural and azido fatty acids inhibit phosphate transport and activate fatty acid anion uniport mediated by the mitochondrial phosphate carrier.
J Biol Chem. 2001 Feb 16;276(7):4683-91

Perovic S, Böhm M, Meesters E, Meinhardt A, Pergande G, Müller WE.
Pharmacological intervention in age-associated brain disorders by Flupirtine: Alzheimer's and prion diseases.
Mech Ageing Dev. 1998 Mar 16;101(1-2):1-19.