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Dr. Jens Friedrichs

Institute of Biofunctional Polymer Materials
+49 351 4658 595/ 623 +49 351 4658 533

Personal Data

  • 2005 - 2009: – PhD at the Biotechnology Center of TU Dresden in the research group of Prof. Daniel Müller
  • 2010: research scientist at the Biotechnology Center of TU Dresden
  • since 2011: – research scientist at Leibniz Institute of Polymer Research Dresden

Fields of Work

• Understand the functional principles of biofouling and biofouling resistance (in nature)

• Develop novel (amphiphilic) biofouling resistant surfaces

• Application of atomic force microscopy-based methods to various fields of research; including (quantitative) imaging, (single cell) force spectroscopy, nanoindentation

Publications

  • Husman, D. ; Welzel, P. ; Vogler, S. ; Bray, L. ; Träber, N. ; Friedrichs, J. ; Körber, V. ; Tsurkan, M. ; Freudenberg, U. ; Thiele, J. ; Werner, C. Multiphasic microgel-in-gel materials to recapitulate cellular mesoevironments in vitro more Biomaterials Science 2020 (2020) 101-108
  • Sievers, J. ; Zschoche, St. ; Dockhorn, R. ; Friedrichs, J. ; Werner, C. ; Freudenberg, U. Temperature-Induced mechanomodulation of interpenetrating networks of star poly(ethylene glycol)-heparin and poly(N-isopropylacrylamide) more ACS Applied Materials & Interfaces 11 (2019) 41862-41874
  • Lee, P.S. ; Hess, R. ; Friedrichs, J. ; Haenchen, V. ; Eckert, H. ; Cuniberti, G. ; Rancourt, D. ; Krawetz, R. ; Hintze, V. ; Gelinsky, M. ; Scharnweber, D. Recapitulating bone development events in a customised bioreactor through interplay of oxygen tension, medium pH, and systematic differentiation approaches more Journal of Tissue Engineering and Regenerative Medicine (2019) Early View
  • Träber, N. ; Uhlmann, K. ; Girardo, S. ; Kesavan, G. ; Wagner, K. ; Friedrichs, J. ; Goswami, R. ; Bai, K. ; Brand, M. ; Werner, C. ; Balzani, D. ; Guck, J. Polyacrylamide bead sensors for in vivo quantification of cell-scale stress in zebrafish development more bioRxiv the Preprint Server for Biology (2019) article preprint
  • Choi, S. ; Friedrichs, J. ; Song, Y. H. ; Werner, C. ; Estroff, L. ; Fischbach-Teschl, C. Intrafibrillar, bone-mimetic collagen mineralization regulates breast cancer cell adhesion and migration more Biomaterials 198 (2019) 95-106
  • Zimmermann, R. ; Delius, J. ; Friedrichs, J. ; Stehl, S. ; Hofmann, T. ; Hannig, C. ; Rehage, M. ; Werner, C. ; Hannig, M. Impact of oral astringent stimuli on surface charge and morphology of the protein-rich pellicle at the tooth-saliva interphase more Colloids and Surfaces B: Biointerfaces 174 (2019) 451-458
  • Papadimitriou, C. ; Celikkaya, H. ; Cosacak, M. I. ; Mashkaryan, V. ; Bray, L. ; Bhattarai, P. ; Brandt, K. ; Hollak, H. ; Chen, X. ; He, S. ; Antos, C. L. ; Lin, W. ; Thomas, A. K. ; Dahlina, A. B. ; Kurth, T. ; Friedrichs, J. ; Zhang, Y. ; Freudenberg, 3D culture method for alzheimers disease modeling reveals interleukin-4 rescues A beta 42-induced Loss of human neural stem cell plasticity more Developmental Cell 46 (2018) 85-101
  • Newland, B. ; Taplan, C. ; Pette, D. ; Friedrichs, J. ; Steinhart, M. ; Wang, W. ; Voit, B. ; Werner, C. Soft and flexible poly(ethylene glycol) nanotubes for local drug delivery more Nanoscale 10 (2018) 8413-8421
  • Thomas, A. K. ; Wieduwild, R. ; Zimmermann, R. ; Lin, W. ; Friedrichs, J. ; Bickle, M. ; Fahmy, K. ; Werner, C. ; Zhang, Y. Layer-by-layer assembly of heparin and peptide-polyethylene glycol conjugates to form hybrid nanothin films of biomatrices more ACS Applied Materials & Interfaces 10 (2018) 14264-14270
  • Arulmozhivarman, G. ; Krater, M. ; Wobus, M. ; Friedrichs, J. ; Bejestani, E. P. ; Müller, K. ; u.a., Zebrafish in-vivo screening for compounds amplifying hematopoietic stem and progenitor cells: - Preclinical validation in human CD34+stem and progenitor cells more Scientific Reports 7 (2017) ID12084
  • Mulansky, S. ; Saballus, M. ; Friedrichs, J. ; Bley, Th. ; Boschke, E. A novel protocol to prepare cell probes for the quantification of microbial adhesion and biofilm initiation on structured bioinspired surfaces using AFM for single-cell force spectroscopy more Engineering in Life Science 17 (2017) 833-840
  • Magno, V. ; Friedrichs, J. ; Weber, H. ; Prewitz, M. ; Tsurkan, M. ; Werner, C. Macromolecular crowding for tailoring tissue-derived fibrillated matrices more Acta Biomaterialia 55 (2017) 109-119
  • Binner, M. ; Bray, L. ; Friedrichs, J. ; Tsurkan, M. ; Werner, C. Cell-instructive starPEG-heparin-collagen composite matrices more Acta Biomaterialia 53 (2017) 70-80
  • Kirillova, A. ; Marschelke, C. ; Friedrichs, J. ; Werner, C. ; Synytska, A. Hybrid hairy Janus particles as novel building blocks for antifouling surfaces more ACS Applied Materials & Interfaces 8 (2016) 32591-32603
  • Borg, D. ; Welzel, P. ; Grimmer, M. ; Friedrichs, J. ; Weigelt, M. ; Wilhelm, C. ; Prewitz, M. ; Stißel, A. ; Hommel, A. ; Kurth, T. ; Freudenberg, U. ; Bonifacio, E. ; Werner, C. Macroporous biohybrid cryogels for co-housing pancreatic islets with mesenchymal stromal cells more Acta Biomaterialia 44 (2016) 178-187
  • Zimmermann, R. ; Friedrichs, J. ; Lanfer, B. ; Freudenberg, U. ; Werner, C. Aligned fibrillar collagen matrices more Wiley 1 (2016) Chapter 27, 340-354
  • Helbig, R. ; Günther, D. ; Friedrichs, J. ; Rößler, F. ; Lasagni, A. ; Werner, C. The impact of structure dimensions on initial bacterial adhesion more Biomaterials Science 2016 (2016) 1074-1078
  • Dhawan, A. ; Friedrichs, J. ; Bonin, M. v. ; Bejestani, E. P. ; Werner, C. ; Wobus, M. ; Chavakis, T. ; Bornhäuser, M. Breast cancer cells compete with hematopoietic stem and progenitor cells for intercellular adhesion molecule 1-mediated binding to the bone marrow microenvironment more Carcinogenesis 37 (2016) 759-767
  • Poitz, D. M. ; Ende, G. ; Stütz, B. ; Augstein, A. ; Friedrichs, J. ; Brunnssen, C. ; Werner, C. ; Strasser, R. H. ; Jellinghaus, S. EphrinB2/EphA4-mediated activation of endothelial cells increases monocyte adhesion more Molecular Immunology 68 (2015) 648-656
  • Prewitz, M. ; Stißel, A. ; Friedrichs, J. ; Träber, N. ; Vogler, S. ; Bornhäuser, M. ; Werner, C. Extracellular matrix deposition of bone marrow stroma enhanced by macromolecular crowding more Biomaterials 73 (2015) 60-69
  • Reichert, D. ; Friedrichs, J. ; Ritter, S. ; Käubler, T. ; Werner, C. ; Bornhäuser, M. ; Corbeil, D. Phenotypic, morphological and adhesive differences of human hematopoietic progenitor cells cultured on murine versus human mesenchymal stromal cells more Scientific Reports 5 (2015) Article number: 15680
  • Friedrichs, J. ; Werner, C. Polymeric coatings to fight biofouling more Springer (2015) 1944-1950
  • Amornsudthiwat, P. ; Nitschke, M. ; Zimmermann, R. ; Friedrichs, J. ; Grundke, K. ; Pöschel, K. ; Damrongsakkul, S. ; Werner, C. Comprehensive characterization of well-defined silk fibroin surfaces: Toward multitechnique studies of surface modification effects more Biointerphases 10 (2015) 029501
  • Fischer, M. ; Vahdatzadeh, M. ; Konradi, R. ; Friedrichs, J. ; Maitz, M.F. ; Freudenberg, U. ; Werner, C. Multilayer hydrogel coatings to combine hemocompatibility and antimicrobial activity more Biomaterials 56 (2015) 198-205
  • Bray, L. ; Binner, M. ; Holzheu, A. ; Friedrichs, J. ; Freudenberg, U. ; Hutmacher, D. W. ; Werner, C. Multi-parametric hydrogels support 3D in vitro bioengineered microenvironment models of tumour angiogenesis more Biomaterials 53 (2015) 609-620