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Authors
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Rother, S. ; Krönert, V. ; Hauck, N. ; Berg, A. ; Möller, S. ; Schnabelrauch, M. ; Thiele, J. ; Scharnweber, D. ; Hintze, V.
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Title
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Hyaluronan/collagen hydrogel matrices containing high-sulfated hyaluronan microgels for regulating transforming growth factor-ß1
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Date
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24.05.2019
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Number
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56813
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Abstract
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Hyaluronan (HA)-based microgels generated in a microfluidic approach, containing an artificial extracellular matrix composed of collagen and high-sulfated hyaluronan (sHA3), were incorporated into a HA/collagen-based hydrogel matrix. This significantly enhanced the retention of noncrosslinked sHA3 within the gels enabling controlled sHA3 presentation. Gels containing sHA3 bound higher amounts of transforming growth factor-ß1 (TGF-ß1) compared to pure HA/collagen hydrogels. Moreover, the presence of sHA3-containing microgels improved the TGF-ß1 retention within the hydrogels. These findings are promising for developing innovative biomaterials with adjustable sHA3 release and growth factor interaction profiles to foster skin repair, e.g., by rebalancing dysregulated TGF-ß1 levels.
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Publisher
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Journal of Materials Science : Materials in Medicine
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Wikidata
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Citation
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Journal of Materials Science : Materials in Medicine 30 (2019) Article Number: 65
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DOI
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https://doi.org/10.1007/S10856-019-6267-1
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