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Authors Chae, S. ; Jung, J.H. ; Choi, W.J. ; Park, J.K. ; Baik, H.K. ; Ko, H.W.
Title Multilayer fabrication of unobtrusive poly(dimethylsiloxane) nanobrush for tunable cell adhesion
Date 27.02.2019
Number 56464
Abstract Precise modulation of polymer brush in its thickness and grafting density can cause unexpected cell behaviors and regulated bioactivities. Herein, a nanoscale poly(dimethylsiloxane) (PDMS) brush was employed to use as a controllable material for cell adhesion. Facile fabrication of ultrathin monolayer PDMS nanobrush on an underlying substrate facilitated regaining cell adhesion through long-range cell attractive forces such as the van der Waals forces. We showed that cell adhesion is diminished by increasing the number of nanobrush layers, causing a gradual decrease of the effectiveness of the long-range force. The result demonstrates that ultrathin PDMS nanobrush can either promote or inhibit cell adhesion, which is required for various biomedical fields such as tissue-engineering, anti-fouling coating, and implantable biomaterials and sensors.
Publisher Scientific Reports
Wikidata
Citation Scientific Reports 9 (2019) ID1834
DOI https://dx.doi.org/10.1038%2Fs41598-018-37893-w
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