Authors
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Chae, S. ; Jung, J.H. ; Choi, W.J. ; Park, J.K. ; Baik, H.K. ; Ko, H.W.
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Title
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Multilayer fabrication of unobtrusive poly(dimethylsiloxane) nanobrush for tunable cell adhesion
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Date
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27.02.2019
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Number
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56464
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Abstract
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Precise modulation of polymer brush in its thickness and grafting density can cause unexpected cell behaviors and regulated bioactivities. Herein, a nanoscale poly(dimethylsiloxane) (PDMS) brush was employed to use as a controllable material for cell adhesion. Facile fabrication of ultrathin monolayer PDMS nanobrush on an underlying substrate facilitated regaining cell adhesion through long-range cell attractive forces such as the van der Waals forces. We showed that cell adhesion is diminished by increasing the number of nanobrush layers, causing a gradual decrease of the effectiveness of the long-range force. The result demonstrates that ultrathin PDMS nanobrush can either promote or inhibit cell adhesion, which is required for various biomedical fields such as tissue-engineering, anti-fouling coating, and implantable biomaterials and sensors.
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Publisher
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Scientific Reports
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Wikidata
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Citation
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Scientific Reports 9 (2019) ID1834
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DOI
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https://dx.doi.org/10.1038%2Fs41598-018-37893-w
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Tags
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