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Authors
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Franiak-Pietryga, I. ; Ostrowska, K. ; Maciejewski, H. ; Appelhans, D. ; Misiewicz, M. ; Ziemba, B. ; Bednarek, M. ; Bryszewska, M. ; Borowiec, M.
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Title
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PPI-G4 glycodendrimers upregulates TRAIL-induced apoptosis in chronic lymphocytic leukemia cells
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Date
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05.05.2017
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Number
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49828
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Abstract
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Although chronic lymphocytic leukemia (CLL) is the most common adult leukemia in Western world, it remains incurable with conventional chemotherapeutic agents. Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is an antitumor candidate in cancer therapy. This study examines the proapoptotic effects of poly(propylene imine) (PPI) glycodendrimers modified with the maltotriose residues (PPI-G4-OS-Mal-III and PPI-G4-DS-Mal-III) on the TNF family in CLL cells. The combination of an understanding of the signaling pathways associated with CLL and the development of a molecular profiling is a key issue for the design of personalized approaches to therapy. Gene expression is determined with two-color microarray 8 × 60K. The findings indicate that PPI-G4-OS/DS-Mal-III affect gene expression from the TRAIL apoptotic pathway and exert a strong effect on CLL cells comparable with fludarabine. Dendrimer-targeted technology may well prove to bridge the gap between the ineffective treatment of today and the effective personalized therapy of the future.
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Publisher
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Macromolecular Bioscience
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Wikidata
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Citation
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Macromolecular Bioscience 17 (2017) ID1600169
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DOI
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https://doi.org/10.1002/mabi.201600169
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