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Authors
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Werner, C.
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Title
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Editorial - cell-instructive hydrogels to assemble in biofluids
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Date
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22.08.2013
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Number
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38884
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Abstract
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Embedding cells in engineered polymer matrices, which mimic fundamental characteristics of naturally occurring extracellular microenvironments, is a key task in the rapidly progressing fields of tissue engineering and regenerative medicine. Importantly, cell-instructive matrix signals including matrix-associated growth factors, ligands of cellular adhesion receptors, intrinsic viscoelastic properties and susceptibility for cell-driven reorganization have to be presented in a spatiotemporally adjusted manner.<br /><br />For that purpose, the current practice in cell biology and biotechnology mostly relies on reconstituting non-covalently associating biopolymer meshworks (collagen fibrils, Matrigel). Although effective in numerous in vitro approaches to cell signaling, these<br />preparations are hardly compatible with safety requirements for medical applications and are often not suitable for the mechanistic investigation of particular exogenous signals.
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Publisher
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eXPRESS Polymer Letters
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Wikidata
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Citation
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eXPRESS Polymer Letters 7 (2013) 805
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DOI
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https://doi.org/10.3144/expresspolymlett.2013.77
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Tags
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