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Dr. Manfred Maitz

Institute of Biofunctional Polymer Materials
+49 351 4658 606/ 313 +49 351 4658 533

Personal Data

Manfred Maitz is responsible for the field of hemocompatible surfaces in the Institute Biofunctional Polymer Materials. He is a medical doctor (Dr. med.) by education and has been working on biomaterials research in institutes in Würzburg, Ulm, Magdeburg, Dresden and Chengdu (PR China) before he joined the IPF in 2006.

He is Guest Professor at Southwest Jiaotong University, School of Materials Science and Engineering in Chengdu, China, where he has annual research stays as guest scientist.

His focus of research is on feedback responsive materials to control blood coagulation and inflammatory responses at biomaterials in blood. These are important as vascular stents, artificial heart valves, hemodialysis membranes or tubings for extracorporeal circulation, etc.

He is member of the WTR in the IPF.

 Research experiences

2006 – presentResearch Fellow and Group Leader, Leibniz Institute of Polymer Research Dresden, Max Bergmann Center of Biomaterials Dresden, Germany
2005Foreign Expert scientist, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, China
2000 – 2004Thematic field leader, Research Center Rossendorf, Institute of Ion Beam Physics and Materials Research, Dresden, Germany
1999Assistant, Institute for Pathology, Otto-von-Guericke Universität Magdeburg, Magdeburg, Germany
1998Research Fellow, Central Institute of Biomedical Techniques, University of Ulm, Ulm, Germany

 Membership of Academic Societies

Profiles

Key Publications

  1. Maitz M.F., Zitzmann J., Hanke J., Renneberg C., Tsurkan M.V., Sperling C., Freudenberg U., Werner C. Adaptive release of heparin from anticoagulant hydrogels triggered by different blood coagulation factors. Biomaterials 135: 53-61 (2017). doi:10.1016/j.biomaterials.2017.04.044
  2. Herklotz M., Hanke J., Hänsel S., Drichel J., Marx M., Maitz M.F., Werner C. Biomaterials trigger endothelial cell activation in co-incubation with human whole blood. Biomaterials 104: 258-268 (2016). doi:10.1016/j.biomaterials.2016.07.022
  3. Maitz M.F. Applications of synthetic polymers in clinical medicine. Biosurf Biotribol 1(3): 161-176 (2015). doi:10.1016/j.bsbt.2015.08.002
  4. http://dx.doi.org/10.1016/j.bsbt.2015.08.002Maitz M.F., Freudenberg U., Tsurkan M.V., Fischer M., Beyrich T., Werner C. Bio-responsive polymer hydrogels homeostatically regulate blood coagulation. Nature Commun (2013). doi:10.1038/ncomms3168
  5. Sperling C., Fischer M., Maitz M.F., Werner C. Blood coagulation on biomaterials requires the combination of distinct activation processes. Biomaterials 30(27): 4447-4456 (2009). doi:10.1016/j.biomaterials.2009.05.044
  6. Werner C., Maitz M.F., Sperling C. Current strategies towards hemocompatible coatings. J Mater Chem 17: 3376-3384 (2007). doi:10.1039/b703416b

 

Publications

  • Maitz, M.F. ; Freudenberg, U. ; Tsurkan, M. ; Fischer, M. ; Beyrich, T. ; Werner, C. Bio-responsive polymer hydrogels homeostatically regulate blood coagulation more Nature Communications 4 (2013) 7 Seiten [OPEN]
  • Chen, J. ; Huang, N. ; Ma, B. ; Maitz, M.F. ; Wang, J. ; Li, J. ; Li, Q. ; Zhao, Y. ; Xiong, K. ; Liu, X. Guidance of stem cells to a target destination in vivo by magnetic nanoparticles in a magnetic field more ACS Applied Materials & Interfaces 5 (2013) 5976-5985
  • Liu, S. ; Liu, T. ; Chen, J. ; Maitz, M.F. ; Chen, C. ; Huang, N. Influence of a layer-by layer-assembled multilayer of anti-CD34 antibody, vascular endothelial growth factor, and heparin on the endothelialization and anticoagulation of titanium surface more Journal of Biomedical Materials Research Part A 101 (2013) 1144-1157
  • Xie, D. ; Wan, G. ; Maitz, M.F. ; Sun, H. ; Huang, N. Deformation and corrosion behaviors of Ti-O film deposited 316L stainless steel by plasma immersion ion implantation and deposition more Surface & Coatings Technology 214 (2013) 117-123
  • Tu, Q. ; Yang, Z. ; Zhu, Y. ; Xiong, K. ; Maitz, M.F. ; Wang, J. ; Zhao, Y. ; Huang, N. ; Jin, J. ; Lei, Y. Effect of tissue specificity on the performance of extracellular matrix in improving endothelialization of cardiovascular implants more Tissue Engineering A 19 (2013) 91-102
  • Xie, D. ; Wan, G. ; Maitz, M.F. ; Lei, Y. ; Huang, N. ; Sun, H. Characterization and mechanical investigation of Ti-O2-x film prepared by plasma immersion ion implantation and deposition for cardiovascular stents surface modification more Nuclear Instruments and Methods in Physics Research B 289 (2012) 91-96
  • Chen, J. ; Wang, J. ; Qi, P. ; Li, X. ; Ma, B. ; Chen, Z. ; Li, Q. ; Zhao, Y. ; Xiong, K. ; Maitz, M.F. ; Huang, N. Biocompatibility studies of poly(ethylene glycol)-modified titanium for cardiovascular devices more Journal of Bioactive and Compatible Polymers 27 (2012) 565-584
  • Yang, Z. ; Tu, Q. ; Zhu, Y. ; Luo, R. ; Li, X. ; Xie, Y. ; Maitz, M.F. ; Wang, J. ; Huang, N. Mussel-inspired coating of polydopamine directs endothelial and smooth muscle cell fate for re-endothelialization of vascular devices more Advanced Healthcare Materials 1 (2012) 548-559
  • Yang, Z. ; Tu, Q. ; Maitz, M.F. ; Zhou, S. ; Wang, J. ; Huang, N. Direct thrombin inhibitor-bivalirudin functionalized plasma polymerized allylamine coating for improved biocompatibility of vascular devices more Biomaterials 33 (2012) 7959-7971
  • Lu, Lei ; Li, Q. ; Maitz, M.F. ; Chen, J. ; Huang, N. Immobilization of the direct thrombin inhibitor-bivalirudin on 316L stainless steel via polydopamine and the resulting effects on hemocompatibility in vitro more Journal of Biomedical Materials Research Part A 100 (2012) 2421-2430
  • Wan, G. ; Solovev, A. A. ; Huang, G. S. ; Maitz, M.F. ; Huang, N. ; Mai, Y. F. Dynamic curvature control of rolled-up metal nanomembranes activated by magnesium more Journal of Materials Chemistry 22 (2012) 12983-12987
  • Weng, Y. ; Chen, J. ; Tu, Q. ; Li, Q. ; Maitz, M.F. ; Huang, N. Biomimetic modification of metallic cardiovascular biomaterials: from function mimicking to endothelialization in vivo more Interface Focus 2 (2012) 356-365
  • Chen, J. ; Cao, J. ; Wang, J. ; Maitz, M.F. ; Guo, L. ; Zhao, Y. ; Li, Q. ; Xiong, K. ; Huang, N. Biofunctionalization of titanium with PEG and anti-CD34 for hemocompatibility and stimulated endothelialization more Journal of Colloid and Interface Science 368 (2012) 636-647
  • Seib, P. ; Maitz, M.F. ; Hu, X. ; Werner, C. ; Kaplan, D. L. Impact of processing parameters on the haemocompatibility of bombyx mori silk films more Biomaterials 33 (2012) 1017-1023
  • Liebner, F. ; Dunareanu, R. ; Opietnik, M. ; Haimer, E. ; Wendland, M. ; Werner, C. ; Maitz, M.F. ; Seib, P. ; Neouze, M.-A. ; Potthast, A. ; Rosenau, T. Shaped hemocompatible aerogels from cellulose phosphates: Preparation and properties more Holzforschung : international journal of the biology, chemistry, physics and technology of wood 66 (2012) 317-321
  • Li, G. ; Yang, P. ; Qin, W. ; Maitz, M.F. ; Zhou, S. ; Huang, N. The effect of coimmobilizing heparin and fibronectin on titanium on hemocompatibility and endothelialization more Biomaterials 32 (2011) 4691-4703
  • Maitz, M.F. ; Sperling, C. ; Werner, C. Immobilization of the irreversible thrombin inhibitor D-Phe-Pro-Arg-chloromethylketone: A concept for hemocompatible surfaces? more Journal of Biomedical Materials Research Part A 94 (2010) 905-912
  • Yang, Z. ; Wang, J. ; Luo, R. ; Maitz, M.F. ; Jing, F. ; Sun, H. ; Huang, N. The covalent immobilization of heparin to pulsed-plasma polymeric allylamine films on 316L stainless steel and the resulting effects on hemocompatibility more Biomaterials 31 (2010) 2072-2083
  • Sperling, C. ; Fischer, M. ; Maitz, M.F. ; Werner, C. Blood coagulation on biomaterials requires combination of distinct activation processes more Biomaterials 30 (2009) 4447-4456
  • Maitz, M.F. ; Teichmann, J. ; Sperling, C. ; Werner, C. Surface endotoxin contamination and hemocompatibiliy evaluation of materials more Journal of Biomedical Materials Research Part B: Applied Biomaterials 90B (2009) 18-25
  • Maitz, M.F. Surface modification of Ni-Ti alloys for biomedical applications more Woodhead Publishing Limited (2008) 173-193
  • Huang, N. ; Ishihara, K. ; Lee, Hai Bang ; Brown, I. G. ; Maitz, M.F. ; Leng, Yongxiang The First International Symposium on Surfaces and Interfaces of Biomaterials more Applied Surface Science 255 (2008) Heft 2, 257-622
  • Werner, C. ; Maitz, M.F. ; Sperling, C. Current strategies towards hemocompatible coatings more Journal of Materials Chemistry 17 (2007) 3376-3384
  • Sperling, C. ; Maitz, M.F. ; Talkenberger, S. ; Gouzy, M.-F. ; Groth, T. ; Werner, C. In vitro blood reactivity to hydroxylated and non-hydroxylated polymer surfaces more Biomaterials 28 (2007) 3617-3625
  • Liu, Y. R. ; Qu, S. X. ; Maitz, M.F. ; Tan, R. ; Weng, J. The effect of the major components of salvia miltiorrhiza bunge on bone marrow cells more Journal of Ethnopharmacology 111 (2007) 573-583