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Authors
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Krieg, E.
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Title
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Programmable DNA-based nanomaterials for biomedical applications
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Date
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02.06.2025
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Number
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0
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Abstract
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Deoxyribonucleic acid (DNA) plays a central role as the carrier of genetic information in all living organisms. However, its unique physicochemical properties also make the DNA molecule interesting for the field of materials science. This chapter describes a class of materials that exhibit “programmable” properties through the use of nanoscopic components made of DNA. The distinctive characteristics of DNA-based nanosystems and DNA-functionalized polymer materials are described, outlining the design strategies that allow the construction of sophisticated supramolecular architectures with predictable, tunable, and reconfigurable characteristics. These materials may enable more efficient diagnostic assays and improved procedures for personalized medicine. The most recent progress in three specific application areas is highlighted as follows: (1) printable and stimuli-responsive DNA-based hydrogels can serve as precision matrices for the in vitro study of human cells and organoids; (2) materials for the isolation and purification of nucleic acids from biological and clinical samples enable more efficient next-generation sequencing diagnostics; and (3) new DNA-based reaction cascades allow the sensitive identification of specific nucleic acid sequences for cost-effective point-of-care detection assays.
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Publisher
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World Scientific
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Wikidata
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Citation
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in: Advanced Polymer Life Science: Polymer Soft Matter Science & Engineering, Vol. 1 / C. Werner et al. (Eds.). New Jersey [u.a.]: World Scientific, 2025. 345-379 (World Scientific Series on Emerging Technologies; 7); ISBN 978-981-98-0677-5
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DOI
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https://doi.org/10.1142/9789819806782_0010
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