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Authors
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Dewan, S.; Lampel, A.
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Title
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Designed multicomponent glycan-based biopolymer condensates
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Date
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02.06.2025
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Number
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0
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Abstract
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The design of synthetic biomolecular condensates that are formed by liquid–liquid phase separation of various building blocks — including those derived from amino acids, nucleic acids, and synthetic polymers — underscores the wide range of interactions that influence the properties and functions of biomolecular condensates. Of particular interest are naturally occurring glycan-based polymers, such as chitosan, hyaluronic acid, heparin, dextran sulfate (DS), pectin, carrageenan, and alginate. These glycan polymers possess distinctive structural and biochemical properties, making them promising candidates for the construction of synthetic condensates. Thus, the versatile biological roles of glycans and their biocompatibility and biodegradability open tremendous opportunities to utilize glycan-based condensates for a wide range of technologies, from tissue engineering and regenerative medicine to drug delivery and food applications. However, understanding the physicochemical properties of glycans is essential for determining how these condensates form, as well as their stability and functionality. A detailed examination of the features and interactions of these building blocks is critical for designing complex, multicomponent glycan-based condensates with customized functionalities. In this chapter, we focus on the emerging field of glycan-based condensates. We introduce the chemical composition, biological roles, and functionalities of naturally occurring glycan-based polymers and discuss the significance of glycans as building blocks of synthetic condensates. Additionally, we review recent work on the regulation of the properties of glycan condensates and their applications and discuss the remaining challenges and trends in this field.
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Publisher
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World Scientific
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Wikidata
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Citation
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in: Advanced Polymer Life Science: Polymer Soft Matter Science & Engineering, Vol. 1 / C. Werner et al. (Eds.). New Jersey [u.a.]: World Scientific, 2025. 103-142 (World Scientific Series on Emerging Technologies; 7); ISBN 978-981-98-0677-5
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DOI
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https://doi.org/10.1142/9789819806782_0004
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