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Authors
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Clegg, J.; Porter, L. H.; Taylor, R. A.; Lössner, D.
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Title
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Tumour tissue engineering: Modeling prostate cancer with biomaterial-based platforms
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Date
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02.06.2025
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Number
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0
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Abstract
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The extracellular matrix has been recognized as a pivotal component of the tumor microenvironment in cancer tissues. In prostate cancer, the matrix influences the heterogeneous cell populations and vice versa. During cancer initiation and progression, the dynamics of the tumor microenvironment unfold, demonstrating how different cell types contribute to the remodeling of the matrix and how vari-ous molecules influence cell behavior, functions, and responses to treatment. Experimental prostate cancer models traditionally include cell monolayers grown on plastic culture dishes and animal models. Novel three-dimensional (3D) models, such as hydrogels, scaffolds, or microfluidic devices, have emerged as biomaterial-based platforms to accurately resemble cell–cell and cell–matrix interactions as seen in patient tissues. Hydrogels advance 3D tissue models of prostate cancer, providing an intact matrix component with tunable biophysical and biochemical characteristics to suit research needs and dissect complex cellular interactions. The use of hydrogel approaches in prostate cancer research offers to bridge the gap between preclinical studies and clinical applications, by enhancing our understanding of disease mechanisms, therapeutic responses, and drug resistance, and by applying them in drug discovery and drug screening. This chapter focuses on the pathobiology and treatment of prostate cancer, elements of the tumor microenvironment, and currently used biomaterial-based platforms.
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Publisher
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World Scientific
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Wikidata
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Citation
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in: Advanced Polymer Life Science: Polymer Soft Matter Science & Engineering, Vol. 1 / C. Werner et al. (Eds.). New Jersey [u.a.]: World Scientific, 2025. 571-603 (World Scientific Series on Emerging Technologies; 7); ISBN 978-981-98-0677-5
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DOI
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https://doi.org/10.1142/9789819806782_0015
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Tags
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Book Chapters
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