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Authors
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Folini, J. ; Huang, C.-H. ; Anderson, J.C. ; Meier, W. ; Gaitzsch, J.
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Title
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Novel monomers in radical ring-opening polymerisation for biodegradable and pH responsive nanoparticles
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Date
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24.09.2019
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Number
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57183
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Abstract
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Responsive and biodegradable nanoparticles are essential for functional drug delivery systems. We herein report the first pH sensitive polyester from radical ring-opening polymerisation of novel amine-bearing cyclic ketene acetals (CKAs). The CKAs were synthesised via an intermediate carbonate and the resulting polyesters showed a pKa around pH 6. Together with an initial application in biodegradable nanoparticles, they open the pathway for a new generation of functional polyesters.
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Publisher
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Polymer Chemistry
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Wikidata
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Citation
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Polymer Chemistry 10 (2019) 5285-5288
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DOI
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https://doi.org/10.1039/C9PY01103J
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Tags
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