Authors Folini, J. ; Huang, C.-H. ; Anderson, J.C. ; Meier, W. ; Gaitzsch, J.
Title Novel monomers in radical ring-opening polymerisation for biodegradable and pH responsive nanoparticles
Date 24.09.2019
Number 57183
Abstract Responsive and biodegradable nanoparticles are essential for functional drug delivery systems. We herein report the first pH sensitive polyester from radical ring-opening polymerisation of novel amine-bearing cyclic ketene acetals (CKAs). The CKAs were synthesised via an intermediate carbonate and the resulting polyesters showed a pKa around pH 6. Together with an initial application in biodegradable nanoparticles, they open the pathway for a new generation of functional polyesters.
Publisher Polymer Chemistry
Citation Polymer Chemistry 10 (2019) 5285-5288

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