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Dr. Uwe Freudenberg

Institute of Biofunctional Polymer Materials
+49 351 4658 408/ 573 +49 351 4658 533

Personal data

  • 2001-2003: Process Engineer, AMD Saxony Manufacturing LLC & CoKG
  • since 2003: research scientist at the Leibniz Institute of Polymer Research Dresden
  • 2007: PhD at the faculty of Mechanical Engineering of the Technical University of Dresden

Fields of work

  • synthetic and biohybrid matrices for in vivo tissue engineering applications (injectable, functionalized gels)
  • cellulose thin films
  • charge formation processes at polymer interfaces

Publications

  1. Tsurkan, M. ; Wetzel, R. ; Pérez-Hernández, H. ; Chwalek, K. ; Kozlova, A. ; Freudenberg, U. ; Kempermann, G. ; Zhang, Y. ; Lasagni, A. ; Werner, C. Photopatterning of multifunctional hydrogels to direct adult neural precursor cells more Advanced Healthcare Materials 4 (2015) 516-521
  2. Zieris, A. ; Dockhorn, R. ; Röhrich, A. ; Zimmermann, R. ; Müller, M. ; Welzel, P. ; Tsurkan, M. ; Sommer, J.-U. ; Freudenberg, U. ; Werner, C. Biohybrid networks of selectively desulfated glycosaminoglycans for tunable growth factor delivery more Biomacromolecules 15 (2014) 4439-446
  3. Tsurkan, M. ; Chwalek, K. ; Schoder, M. ; Freudenberg, U. ; Werner, C. Chemoselective peptide functionalization of starPEG-GAG hydrogels more Bioconjugate Chemistry 25 (2014) 1942–1950
  4. Welzel, P. ; Friedrichs, J. ; Grimmer, M. ; Vogler, S. ; Freudenberg, U. ; Werner, C. Cryogel micromechanics unraveled by atomic force microscopy-based nanoindentation more Advanced Healthcare Materials 3 (2014) 1849-1853
  5. Chwalek, K. ; Tsurkan, M. ; Freudenberg, U. ; Werner, C. Glycosaminoglycan-based hydrogels to modulate heterocellular communication in in vitro angiogenesis models more Scientific Reports 4 (2014) Article number: 4414
  6. Joly, P. ; Duda, G. N. ; Schöne, M. ; Welzel, P. ; Freudenberg, U. ; Werner, C. ; Petersen, A. Geometry-driven cell organization determines tissue growths in scaffold pores: Consequences for fibronectin organization more PLoS ONE 8 (2013) e73545
  7. Maitz, M.F. ; Freudenberg, U. ; Tsurkan, M. ; Fischer, M. ; Beyrich, T. ; Werner, C. Bio-responsive polymer hydrogels homeostatically regulate blood coagulation more Nature Communications 4 (2013) 7 Seiten [OPEN]
  8. Krüger, K. ; Terne, C. ; Werner, C. ; Freudenberg, U. ; Jankowski, V. ; Zidek, W. ; Jankowski, J. Characterization of polymer membranes by MALDI-mass-spectrometric imaging techniques more Analytical Chemistry 85 (2013) S, 4998-5004
  9. Tsurkan, M. ; Chwalek, K. ; Prokoph, S. ; Zieris, A. ; Levental, K. ; Freudenberg, U. ; Werner, C. Defined polymer-peptide conjugates to form cell-instructive star PEG-heparin matrices in situ more Advanced Materials 25 (2013) 2606-2610
  10. Tsurkan, M. ; Hauser, P. V. ; Zieris, A. ; Carvalhosa, R. ; Bussolati, B. ; Freudenberg, U. ; Gamussi, G. ; Werner, C. Growth factor delivery from hydrogel particle aggregates to promote tubular regeneration after acute kidney injury more Journal of Controlled Release 167 (2013) 248-255
  11. Wieduwild, R. ; Tsurkan, M. ; Chwalek, K. ; Murawala, P. ; Nowak, M. ; Freudenberg, U. ; Neinhuis, C. ; Werner, C. ; Zhang, Y. Minimal peptide motif for non-covalent peptide-heparin hydrogels more Journal of the American Chemical Society 135 (2013) 2919-2922
  12. Zieris, A. ; Werner, C. ; Prokoph, S. ; Levental, K. ; Welzel, P. ; Chwalek, K. ; Schneider, K. ; Freudenberg, U. Sustainable growth factor delivery through affinity-based adsorption to star PEG-heparin hydrogels more American Chemical Society 1120 (2012) Chapter 24, 525-541
  13. Zimmermann, R. ; Bartsch, S. ; Freudenberg, U. ; Werner, C. Electrokinetic analysis to reveal composition and structure of biohybrid hydrogels more Analytical Chemistry 84 (2012) 9592-9595
  14. Welzel, P. ; Grimmer, M. ; Renneberg, C. ; Naujox, L. ; Zschoche, St. ; Freudenberg, U. ; Werner, C. Macroporous starPEG-heparin cryogels more Biomacromolecules 13 (2012) 2349-2358
  15. Baumann, L. ; Prokoph, S. ; Gabriel, C. ; Freudenberg, U. ; Werner, C. ; Beck-Sickinger, A. G. A novel, biased-like SDF-1 derivative acts synergistically with star PEG -based heparin hydrogels and improves eEPC migration in vitro more Journal of Controlled Release 162 (2012) 68–75
  16. Prokoph, S. ; Chavakis, E. ; Levental, K. ; Zieris, A. ; Freudenberg, U. ; Dimmeler, S. ; Werner, C. Sustained delivery of SDF-1a from heparin-based hydrogels to attract circulating pro-angiogenic cells more Biomaterials 33 (2012) 4792-4800
  17. Freudenberg, U.; Sommer, J.-U.; Levental, K.; Welzel, P; Zieris, A.; Chwalek, K.; Schneider, K.; Prokoph, S.; Prewitz, M.; Dockhorn, R.; Werner, C. Using Mean Field Theory to Guide Biofunctional Materials Design more Advanced Functional Materials 22 (2012) 1391-1398
  18. Chwalek, K. ; Levental, K. ; Tsurkan, M. ; Zieris, A. ; Freudenberg, U. ; Werner, C. Two-tier hydrogel degradation to boost endothelial cell morphogenesis more Biomaterials 32 (2011) 9649-9657
  19. Zieris, A. ; Chwalek, K. ; Prokoph, S. ; Levental, K. ; Welzel, P. ; Freudenberg, U. ; Werner, C. Dual independent delivery of pro-angiogenic growth factors from starPEG-heparin hydrogels more Journal of Controlled Release 156 (2011) 28-36
  20. Welzel, P. ; Prokoph, S. ; Zieris, A. ; Grimmer, M. ; Zschoche, St. ; Freudenberg, U. ; Werner, C. Modulating biofunctional starPEG heparin hydrogels by varying size and ratio of the constituents more Polymers [Open Access] 3 (2011) 602-620
  21. Sommer, J.-U. ; Dockhorn, R. ; Welzel, P. ; Freudenberg, U. ; Werner, C. Swelling equilibrium of a binary polymer gel more Macromolecules 44 (2011) 981–986
  22. Zieris, A. ; Prokoph, S. ; Levental, K. ; Welzel, P. ; Grimmer, M. ; Freudenberg, U. ; Werner, C. FGF-2 and VEGF functionalization of starPEG-heparin hydrogels to modulate biomolecular and physical cues of angiogenesis more Biomaterials 31 (2010) 7985-7994
  23. Tsurkan, M. ; Chwalek, K. ; Levental, K. ; Freudenberg, U. ; Werner, C. Modular starPEG-heparin gels with bifunctional peptide linkers more Macromolecular Rapid Communications 31 (2010) 1529-1533
  24. Müller, Y. ; Tot, I. ; Potthast, A. ; Rosenau, T. ; Zimmermann, R. ; Eichhorn, K.-J. ; Nitschke, C. ; Scherr, G. ; Freudenberg, U. ; Werner, C. The impact of esterification reactions on physical properties of cellulose thin films more Soft Matter 6 (2010) 3680-3684
  25. Zimmermann, R. ; Freudenberg, U. ; Schweiß, R. ; Küttner, D. ; Werner, C. Hydroxide and hydronium ion adsorption - A survey more Current Opinion in Colloid and Interface Science 15 (2010) 196-202