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Dr. Uwe Freudenberg

Institute of Biofunctional Polymer Materials
+49 351 4658 408/ 573 +49 351 4658 533

Personal data

  • 2001-2003: Process Engineer, AMD Saxony Manufacturing LLC & CoKG
  • since 2003: research scientist at the Leibniz Institute of Polymer Research Dresden
  • 2007: PhD at the faculty of Mechanical Engineering of the Technical University of Dresden

Fields of work

  • synthetic and biohybrid matrices for in vivo tissue engineering applications (injectable, functionalized gels)
  • cellulose thin films
  • charge formation processes at polymer interfaces

Publications

  • Borg, D. ; Welzel, P. ; Grimmer, M. ; Friedrichs, J. ; Weigelt, M. ; Wilhelm, C. ; Prewitz, M. ; Stißel, A. ; Hommel, A. ; Kurth, T. ; Freudenberg, U. ; Bonifacio, E. ; Werner, C. Macroporous biohybrid cryogels for co-housing pancreatic islets with mesenchymal stromal cells more Acta Biomaterialia (2016) In press
  • Dhawan, A. ; von Bonin, M. ; Bray, L. ; Freudenberg, U. ; Bejestani, E. P. ; Werner, C. ; Hofbauer, L. C. ; Wobus, M. ; Bornhäuser, M. Functional interference in the bone marrow microenvironment by disseminated breast cancer cells more Stem Cells 34 (2016) 2224–2235
  • Taubenberger, A. ; Bray, L. ; Haller, B. ; Shaposhnykov, A. ; Binner, M. ; Freudenberg, U. ; Guck, J. ; Werner, C. 3D extracellular matrix interactions modulate tumour cell growth, invasion and angiogenesis in engineered tumour microenvironments more Acta Biomaterialia 36 (2016) 73-85
  • Lohmann, N. ; Schirmer, L. ; Wandel, E. ; Atallah, P. ; Forstreuter, I. ; Ferrer, R. A. ; Freudenberg, U. ; Werner, C. ; Simon, J. C. ; Franz, S. Immunomodulatory potential of starPEG heparin hydrogels on wound healing associated chemokines more Experimental Dermatology 25 (2016) E8
  • Freudenberg, U. ; Zieris, A. ; Chwalek, K. ; Tsurkan, M. ; Maitz, M.F. ; Atallah, P. ; Levental, K. ; Eming, S. A. ; Werner, C. Heparin desulfation modulates VEGF release and angiogenesis in diabetic wounds more Journal of Controlled Release 220 (2015) 79-88
  • Newland, B. ; Welzel, P. ; Newland, H. ; Renneberg, C. ; Kolar, P. ; Tsurkan, M. ; Rosser, A. ; Freudenberg, U. ; Werner, C. Tackling cell transplantation anoikis: An injectable, shape memory cryogel microcarrier platform material for stem cell and neuronal cell growth more Small 11 (2015) 5047-5053
  • Schurig, K. ; Werner, C. ; Zieris, A. ; Hermann, A. ; Freudenberg, U. ; Heidel, S. ; Grimmer, M. ; Storch, A. Neurotropic growth factors and glycosaminoglycan based matrices to induce dopaminergic tissue formation more Biomaterials 67 (2015) 205-213
  • Watarai, A. ; Schirmer, L. ; Thönes, S. ; Freudenberg, U. ; Werner, C. ; Simon, J. C. ; Anderegg, U. TGFß functionalized starPEG-heparin hydrogels modulate human dermal fibroblast growth and differentiation more Acta Biomaterialia 25 (2015) 65-75
  • Fischer, M. ; Vahdatzadeh, M. ; Konradi, R. ; Friedrichs, J. ; Maitz, M.F. ; Freudenberg, U. ; Werner, C. Multilayer hydrogel coatings to combine hemocompatibility and antimicrobial activity more Biomaterials 56 (2015) 198-205
  • Bray, L. ; Binner, M. ; Holzheu, A. ; Friedrichs, J. ; Freudenberg, U. ; Hutmacher, D. W. ; Werner, C. Multi-parametric hydrogels support 3D in vitro bioengineered microenvironment models of tumour angiogenesis more Biomaterials 53 (2015) 609-620
  • Tsurkan, M. ; Wetzel, R. ; Pérez-Hernández, H. ; Chwalek, K. ; Kozlova, A. ; Freudenberg, U. ; Kempermann, G. ; Zhang, Y. ; Lasagni, A. ; Werner, C. Photopatterning of multifunctional hydrogels to direct adult neural precursor cells more Advanced Healthcare Materials 4 (2015) 516-521
  • Zieris, A. ; Dockhorn, R. ; Röhrich, A. ; Zimmermann, R. ; Müller, M. ; Welzel, P. ; Tsurkan, M. ; Sommer, J.-U. ; Freudenberg, U. ; Werner, C. Biohybrid networks of selectively desulfated glycosaminoglycans for tunable growth factor delivery more Biomacromolecules 15 (2014) 4439-446
  • Tsurkan, M. ; Chwalek, K. ; Schoder, M. ; Freudenberg, U. ; Werner, C. Chemoselective peptide functionalization of starPEG-GAG hydrogels more Bioconjugate Chemistry 25 (2014) 1942-1950
  • Welzel, P. ; Friedrichs, J. ; Grimmer, M. ; Vogler, S. ; Freudenberg, U. ; Werner, C. Cryogel micromechanics unraveled by atomic force microscopy-based nanoindentation more Advanced Healthcare Materials 3 (2014) 1849-1853
  • Chwalek, K. ; Tsurkan, M. ; Freudenberg, U. ; Werner, C. Glycosaminoglycan-based hydrogels to modulate heterocellular communication in in vitro angiogenesis models more Scientific Reports 4 (2014) Article number: 4414
  • Joly, P. ; Duda, G. N. ; Schöne, M. ; Welzel, P. ; Freudenberg, U. ; Werner, C. ; Petersen, A. Geometry-driven cell organization determines tissue growths in scaffold pores: Consequences for fibronectin organization more PLoS ONE 8 (2013) e73545
  • Maitz, M.F. ; Freudenberg, U. ; Tsurkan, M. ; Fischer, M. ; Beyrich, T. ; Werner, C. Bio-responsive polymer hydrogels homeostatically regulate blood coagulation more Nature Communications 4 (2013) 7 Seiten [OPEN]
  • Krüger, K. ; Terne, C. ; Werner, C. ; Freudenberg, U. ; Jankowski, V. ; Zidek, W. ; Jankowski, J. Characterization of polymer membranes by MALDI-mass-spectrometric imaging techniques more Analytical Chemistry 85 (2013) S, 4998-5004
  • Tsurkan, M. ; Chwalek, K. ; Prokoph, S. ; Zieris, A. ; Levental, K. ; Freudenberg, U. ; Werner, C. Defined polymer-peptide conjugates to form cell-instructive star PEG-heparin matrices in situ more Advanced Materials 25 (2013) 2606-2610
  • Tsurkan, M. ; Hauser, P. V. ; Zieris, A. ; Carvalhosa, R. ; Bussolati, B. ; Freudenberg, U. ; Gamussi, G. ; Werner, C. Growth factor delivery from hydrogel particle aggregates to promote tubular regeneration after acute kidney injury more Journal of Controlled Release 167 (2013) 248-255
  • Wieduwild, R. ; Tsurkan, M. ; Chwalek, K. ; Murawala, P. ; Nowak, M. ; Freudenberg, U. ; Neinhuis, C. ; Werner, C. ; Zhang, Y. Minimal peptide motif for non-covalent peptide-heparin hydrogels more Journal of the American Chemical Society 135 (2013) 2919-2922
  • Zieris, A. ; Werner, C. ; Prokoph, S. ; Levental, K. ; Welzel, P. ; Chwalek, K. ; Schneider, K. ; Freudenberg, U. Sustainable growth factor delivery through affinity-based adsorption to star PEG-heparin hydrogels more American Chemical Society 1120 (2012) Chapter 24, 525-541
  • Zimmermann, R. ; Bartsch, S. ; Freudenberg, U. ; Werner, C. Electrokinetic analysis to reveal composition and structure of biohybrid hydrogels more Analytical Chemistry 84 (2012) 9592-9595
  • Welzel, P. ; Grimmer, M. ; Renneberg, C. ; Naujox, L. ; Zschoche, St. ; Freudenberg, U. ; Werner, C. Macroporous starPEG-heparin cryogels more Biomacromolecules 13 (2012) 2349-2358
  • Baumann, L. ; Prokoph, S. ; Gabriel, C. ; Freudenberg, U. ; Werner, C. ; Beck-Sickinger, A. G. A novel, biased-like SDF-1 derivative acts synergistically with star PEG -based heparin hydrogels and improves eEPC migration in vitro more Journal of Controlled Release 162 (2012) 68–75