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Dr. Mikhail Tsurkan

Institute of Biofunctional Polymer Materials
+49 351 4658 644 +49 351 4658 533

Fields of work

The research is focused on the development of new Biofunctional Polymer Materials for growth and proliferation of stem cells which includes:

  • Design and synthesis of peptides and proteins for self assembly into biofunctional polymers
  • Incorporation of biological active molecules into PEG hydrogels through rational peptide synthesis

Publications

  1. Tsurkan, M. ; Wetzel, R. ; Pérez-Hernández, H. ; Chwalek, K. ; Kozlova, A. ; Freudenberg, U. ; Kempermann, G. ; Zhang, Y. ; Lasagni, A. ; Werner, C. Photopatterning of multifunctional hydrogels to direct adult neural precursor cells more Advanced Healthcare Materials 4 (2015) 516-521
  2. Thompson, M. ; Tsurkan, M. ; Chwalek, K. ; Bornhäuser, M. ; Schlierf, M. ; Werner, C. ; Zhang, Y. Self-assembling hydrogels crosslinked solely by receptor-ligand interactions: Tunability, rationalization of physical properties and 3D cell culture more Chemistry - A European Journal 21 (2015) 3178-3182
  3. Zieris, A. ; Dockhorn, R. ; Röhrich, A. ; Zimmermann, R. ; Müller, M. ; Welzel, P. ; Tsurkan, M. ; Sommer, J.-U. ; Freudenberg, U. ; Werner, C. Biohybrid networks of selectively desulfated glycosaminoglycans for tunable growth factor delivery more Biomacromolecules 15 (2014) 4439-446
  4. Anitha, A. ; Sowmya, S. ; Sudheesh Kumar, P. T. ; Deepthi, S. ; Chennazhi, K. P. ; Ehrlich, H. ; Tsurkan, M. ; Jayakumar, R. Chitin and chitosan in selected biomedical applications more Progress in Polymer Science 39 (2014) 1644-1667
  5. Tsurkan, M. ; Chwalek, K. ; Schoder, M. ; Freudenberg, U. ; Werner, C. Chemoselective peptide functionalization of starPEG-GAG hydrogels more Bioconjugate Chemistry 25 (2014) 1942–1950
  6. Nickerl, J. ; Tsurkan, M. ; Hensel, R. ; Neinhuis, C. ; Werner, C. The multi-layered protective cuticle of Collembola: a chemical analysis more Journal of the Royal Society Interface 11 (2014) 20140619
  7. Chwalek, K. ; Tsurkan, M. ; Freudenberg, U. ; Werner, C. Glycosaminoglycan-based hydrogels to modulate heterocellular communication in in vitro angiogenesis models more Scientific Reports 4 (2014) Article number: 4414
  8. Ehrlich, H. ; Rigby, J. K. ; Botting, J. ; Tsurkan, M. ; Werner, C. ; Schwille, P. ; Petrasek, Z. ; Pisera, A. ; Simon, P. ; Sivkov, V. N. ; Vyalikh, D. V. ; Molodtsov, S. L. ; Kurek, D. ; Kammer, M. ; Hunoldt, S. ; Born, R. ; Stawski, D. ; Steinhoff, B. Discovery of 505-million-year old chitin in the basal demosponge Vauxia gracilenta more Scientific Reports 3 (2013) 3497
  9. Wysokowski, M. ; Bazhenov, V. V. ; Tsurkan, M. ; Galli, R. ; Stelling, A. ; Stöcker, H. ; Kaiser, S. ; Niederschlag, E. ; Gärtner, G. ; Behm, T. ; Ilan, M. ; Petrenko, A. Y. ; Jesionowski, T. ; Ehrlich, H. Isolation and identification of chitin in three-dimensional skeleton of aplysina fistularis marin sponge more International Journal of Biological Macromolecules 62 (2013) 94-100
  10. Ehrlich, H. ; Kaluzhnaya, O. V. ; Brunner, E. ; Tsurkan, M. ; Ereskovsky, A. ; Ilan, M. ; Tabachnick, K. R. ; Bazhenov, V. V. ; Paasch, S. ; Kammer, M. ; Born, R. ; Stelling, A. ; Galli, R. ; Belikov, S. ; Petrova, O. V. ; Sivkov, V. N. ; Vyalikh, D. V. ; Identification and first insights into the structure and biosynthesis of chitin from the freshwater sponge Spongilla lacustris more Journal of Structural Biology 183 (2013) 474-483
  11. Maitz, M.F. ; Freudenberg, U. ; Tsurkan, M. ; Fischer, M. ; Beyrich, T. ; Werner, C. Bio-responsive polymer hydrogels homeostatically regulate blood coagulation more Nature Communications 4 (2013) 7 Seiten [OPEN]
  12. Ehrlich, H. ; Kaluzhnaya, O. V. ; Tsurkan, M. ; Ereskovsky, A. ; Tabachnick, K. R. ; Ilan, M. ; Stelling, A. ; Galli, R. ; Petrova, O. V. ; Nekipelov, S. V. ; Sivkov, V. N. ; Vyalikh, D. V. ; Born, R. ; Behm, T. ; Ehrlich, A. ; Chernogor, L. I. ; Belikov, First report on chitinous holdfast in sponges (Porifera) more Proceedings of the Royal Society B 280 (2013) 20130339
  13. Tsurkan, M. ; Chwalek, K. ; Prokoph, S. ; Zieris, A. ; Levental, K. ; Freudenberg, U. ; Werner, C. Defined polymer-peptide conjugates to form cell-instructive star PEG-heparin matrices in situ more Advanced Materials 25 (2013) 2606-2610
  14. Tsurkan, M. ; Hauser, P. V. ; Zieris, A. ; Carvalhosa, R. ; Bussolati, B. ; Freudenberg, U. ; Gamussi, G. ; Werner, C. Growth factor delivery from hydrogel particle aggregates to promote tubular regeneration after acute kidney injury more Journal of Controlled Release 167 (2013) 248-255
  15. Wieduwild, R. ; Tsurkan, M. ; Chwalek, K. ; Murawala, P. ; Nowak, M. ; Freudenberg, U. ; Neinhuis, C. ; Werner, C. ; Zhang, Y. Minimal peptide motif for non-covalent peptide-heparin hydrogels more Journal of the American Chemical Society 135 (2013) 2919-2922
  16. Chwalek, K. ; Levental, K. ; Tsurkan, M. ; Zieris, A. ; Freudenberg, U. ; Werner, C. Two-tier hydrogel degradation to boost endothelial cell morphogenesis more Biomaterials 32 (2011) 9649-9657
  17. Ehrlich, H. ; Deutzmann, R. ; Brunner, E. ; Cappellini, E. ; Koon, H. ; Solazzo, C. ; Yang, Y. ; Ashford, D. ; thomas-Oates, J. ; Lubeck, M. ; Baessmann, C. ; Langrock, T. ; Hoffmann, R. ; Wörheide, G. ; Reitner, J. ; Simon, P. ; Tsurkan, M. ; Ereskovsky, Mineralization of the metre-long biosilica structures of glass sponges is templated on hydroxylated collagen more Nature Chemistry 2 (2010) 1084-1088
  18. Ehrlich, H. ; Tsurkan, M. Mineralization of the metre-long biosilica structures of glass sponges is templated on hydroxylated collagen more Nature Chemistry 2 (2010) 1084-1088
  19. Tsurkan, M. ; Chwalek, K. ; Levental, K. ; Freudenberg, U. ; Werner, C. Modular starPEG-heparin gels with bifunctional peptide linkers more Macromolecular Rapid Communications 31 (2010) 1529-1533
  20. Tsurkan, M. ; Levental, K. ; Freudenberg, U. ; Werner, C. Enzymatically degradable heparin-polyethylene glycol gels with controlled mechanical properties more Chemical Communications 46 (2010) 1141-1143