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Dr. Mikhail Tsurkan

Institute of Biofunctional Polymer Materials
+49 351 4658 644 +49 351 4658 533

Fields of work

The research is focused on the development of new Biofunctional Polymer Materials for growth and proliferation of stem cells which includes:

  • Design and synthesis of peptides and proteins for self assembly into biofunctional polymers
  • Incorporation of biological active molecules into PEG hydrogels through rational peptide synthesis

Publications

  • Gvaramia, D. ; Müller, E. ; Müller, K. ; Atallah, P. ; Tsurkan, M. ; Freudenberg, U. ; Bornhäuser, M. ; Werner, C. Combined influence of biophysical and biochemical cues on maintenance and proliferation of hematopoietic stem cells more Biomaterials 138 (2017) 108-117
  • Maitz, M.F. ; Zitzmann, J. ; Hanke, J. ; Renneberg, C. ; Tsurkan, M. ; Sperling, C. ; Freudenberg, U. ; Werner, C. Adaptive release of heparin from anticoagulant hydrogels triggered by different blodd coagulation factors more Biomaterials 135 (2017) 53-61
  • Magno, V. ; Friedrichs, J. ; Weber, H. ; Prewitz, M. ; Tsurkan, M. ; Werner, C. Macromolecular crowding for tailoring tissue-derived fibrillated matrices more Acta Biomaterialia 55 (2017) 109-119
  • Binner, M. ; Bray, L. ; Friedrichs, J. ; Tsurkan, M. ; Werner, C. Cell-instructive starPEG-heparin-collagen composite matrices more Acta Biomaterialia 53 (2017) 70-80
  • Jungnickel, C. ; Tsurkan, M. ; Eogan, K. ; Werner, C. ; Schlierf, M. Bottom-Up structuring and site-selective modification of hydrogels using a two-photon [2+2] cycloaddition of maleimide more Advanced Materials 29 (2017) Art.No. 1603327
  • Nowak, M. ; Freudenberg, U. ; Tsurkan, M. ; Werner, C. ; Levental, K. Modular GAG-matrices to promote mammary epithelial morphogenesis in vitro more Biomaterials 112 (2017) 20-30
  • Seib, P. ; Tsurkan, M. ; Freudenberg, U. ; Kaplan, D. L. ; Werner, C. Heparin-modified polyethylene glycol microparticle aggregates for focal cancer chemotherapy more ACS Biomaterials Science & Engineering 2 (2016) 2287-2293
  • Ehrlich, H. ; Maldonado, M. ; Tsurkan, M. ; ..., ; u.a., Supercontinuum generation in naturally occurring glass sponges spicules more Advanced Optical Materials 4 (2016) 1608-1613
  • Ehrlich, H. ; Motylenko, M. ; Tsurkan, M. ; et al., Multiphase biomineralization: Enigmatic invasive siliceous diatoms produce crystalline calcite more Advanced Functional Materials 26 (2016) 2503-2510
  • Freudenberg, U. ; Zieris, A. ; Chwalek, K. ; Tsurkan, M. ; Maitz, M.F. ; Atallah, P. ; Levental, K. ; Eming, S. A. ; Werner, C. Heparin desulfation modulates VEGF release and angiogenesis in diabetic wounds more Journal of Controlled Release 220 (2015) 79-88
  • Newland, B. ; Welzel, P. ; Newland, H. ; Renneberg, C. ; Kolar, P. ; Tsurkan, M. ; Rosser, A. ; Freudenberg, U. ; Werner, C. Tackling cell transplantation anoikis: An injectable, shape memory cryogel microcarrier platform material for stem cell and neuronal cell growth more Small 11 (2015) 5047-5053
  • Wysokowski, M. ; Motylenko, M. ; Beyer, J. ; ..., ; Tsurkan, M. Extrem biomimetic approach for developing novel chitin-GeO2 nanocomposites with photoluminescent properties more Nano Research 8 (2015) 2288-2301
  • Tsurkan, M. ; Wetzel, R. ; Pérez-Hernández, H. ; Chwalek, K. ; Kozlova, A. ; Freudenberg, U. ; Kempermann, G. ; Zhang, Y. ; Lasagni, A. ; Werner, C. Photopatterning of multifunctional hydrogels to direct adult neural precursor cells more Advanced Healthcare Materials 4 (2015) 516-521
  • Thompson, M. ; Tsurkan, M. ; Chwalek, K. ; Bornhäuser, M. ; Schlierf, M. ; Werner, C. ; Zhang, Y. Self-assembling hydrogels crosslinked solely by receptor-ligand interactions: Tunability, rationalization of physical properties and 3D cell culture more Chemistry - A European Journal 21 (2015) 3178-3182
  • Zieris, A. ; Dockhorn, R. ; Röhrich, A. ; Zimmermann, R. ; Müller, M. ; Welzel, P. ; Tsurkan, M. ; Sommer, J.-U. ; Freudenberg, U. ; Werner, C. Biohybrid networks of selectively desulfated glycosaminoglycans for tunable growth factor delivery more Biomacromolecules 15 (2014) 4439-446
  • Anitha, A. ; Sowmya, S. ; Sudheesh Kumar, P. T. ; Deepthi, S. ; Chennazhi, K. P. ; Ehrlich, H. ; Tsurkan, M. ; Jayakumar, R. Chitin and chitosan in selected biomedical applications more Progress in Polymer Science 39 (2014) 1644-1667
  • Tsurkan, M. ; Chwalek, K. ; Schoder, M. ; Freudenberg, U. ; Werner, C. Chemoselective peptide functionalization of starPEG-GAG hydrogels more Bioconjugate Chemistry 25 (2014) 1942-1950
  • Nickerl, J. ; Tsurkan, M. ; Hensel, R. ; Neinhuis, C. ; Werner, C. The multi-layered protective cuticle of Collembola: a chemical analysis more Journal of the Royal Society Interface 11 (2014) 2014.0619
  • Chwalek, K. ; Tsurkan, M. ; Freudenberg, U. ; Werner, C. Glycosaminoglycan-based hydrogels to modulate heterocellular communication in in vitro angiogenesis models more Scientific Reports 4 (2014) Article number: 4414
  • Ehrlich, H. ; Rigby, J. K. ; Botting, J. ; Tsurkan, M. ; Werner, C. ; Schwille, P. ; Petrasek, Z. ; Pisera, A. ; Simon, P. ; Sivkov, V. N. ; Vyalikh, D. V. ; Molodtsov, S. L. ; Kurek, D. ; Kammer, M. ; Hunoldt, S. ; Born, R. ; Stawski, D. ; Steinhoff, B. Discovery of 505-million-year old chitin in the basal demosponge Vauxia gracilenta more Scientific Reports 3 (2013) 3497
  • Wysokowski, M. ; Bazhenov, V. V. ; Tsurkan, M. ; Galli, R. ; Stelling, A. ; Stöcker, H. ; Kaiser, S. ; Niederschlag, E. ; Gärtner, G. ; Behm, T. ; Ilan, M. ; Petrenko, A. Y. ; Jesionowski, T. ; Ehrlich, H. Isolation and identification of chitin in three-dimensional skeleton of aplysina fistularis marin sponge more International Journal of Biological Macromolecules 62 (2013) 94-100
  • Ehrlich, H. ; Kaluzhnaya, O. V. ; Brunner, E. ; Tsurkan, M. ; Ereskovsky, A. ; Ilan, M. ; Tabachnick, K. R. ; Bazhenov, V. V. ; Paasch, S. ; Kammer, M. ; Born, R. ; Stelling, A. ; Galli, R. ; Belikov, S. ; Petrova, O. V. ; Sivkov, V. N. ; Vyalikh, D. V. ; Identification and first insights into the structure and biosynthesis of chitin from the freshwater sponge Spongilla lacustris more Journal of Structural Biology 183 (2013) 474-483
  • Maitz, M.F. ; Freudenberg, U. ; Tsurkan, M. ; Fischer, M. ; Beyrich, T. ; Werner, C. Bio-responsive polymer hydrogels homeostatically regulate blood coagulation more Nature Communications 4 (2013) 7 Seiten [OPEN]
  • Ehrlich, H. ; Kaluzhnaya, O. V. ; Tsurkan, M. ; Ereskovsky, A. ; Tabachnick, K. R. ; Ilan, M. ; Stelling, A. ; Galli, R. ; Petrova, O. V. ; Nekipelov, S. V. ; Sivkov, V. N. ; Vyalikh, D. V. ; Born, R. ; Behm, T. ; Ehrlich, A. ; Chernogor, L. I. ; Belikov, First report on chitinous holdfast in sponges (Porifera) more Proceedings of the Royal Society B 280 (2013) 20130339
  • Tsurkan, M. ; Chwalek, K. ; Prokoph, S. ; Zieris, A. ; Levental, K. ; Freudenberg, U. ; Werner, C. Defined polymer-peptide conjugates to form cell-instructive star PEG-heparin matrices in situ more Advanced Materials 25 (2013) 2606-2610