Authors
|
Mai, T. ; Boye, S. ; Yuan, J. ; Völkel, A. ; Gräwert, M. ; Günter, C. ; Lederer, A. ; Taubert, A.
|
Title
|
Poly(ethylene oxide)-based block copolymers with very high molecular weights for biomimetic calcium phosphate mineralization
|
Date
|
13.11.2015
|
Number
|
48401
|
Abstract
|
The article is the first report on the effects of poly(ampholyte)s and poly(betaine)s on the biomimetic formation of calcium phosphate. We have synthesized a series of di- and triblock copolymers based on a non-ionic poly(ethylene oxide) block and several charged methacrylate monomers, 2-(Trimethylamino)ethyl methacrylate, 2-((3-Cyanopropyl)-dimethylammonium)ethyl methacrylate chloride, 3-Sulfopropyl methacrylate potassium salt, and [2-(Methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl)ammonium hydroxide. The resulting copolymers are either positively charged, ampholytic, or betaine block copolymers. All polymers have very high molecular weights of over 106 g/mol. All polymers are water-soluble and show a strong effect on the formation and dissolution of calcium phosphate. The strongest effects are observed with triblock copolymers based on a large poly(ethylene oxide) middle block (nominal Mn = 100’000 g/mol). Surprisingly, the data show that there is a need for positive charges in the polymers, but that the exact position of the charge in the polymer is of minor importance for both calcium phosphate precipitation and dissolution.
|
Publisher
|
RSC Advances
|
Wikidata
|
|
Citation
|
RSC Advances 5 (2015) 103494-103505
|
DOI
|
https://doi.org/10.1039/C5RA20035K
|
Tags
|
|