Authors
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Hahner, J. ; Hinüber, C. ; Breier, A. ; Siebert, T. ; Brünig, H. ; Heinrich, G.
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Title
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Adjusting the mechanical behavior of embroidered scaffolds to lapin anterior cruciate ligaments by varying the thread materials
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Date
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14.05.2015
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Number
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46422
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Abstract
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Traumatic rupture of the anterior cruciate ligament (ACL) can cause local destabilization and loss of mobility. Reconstruction using engineered ACL grafts is rarely successful due to sub-optimal material choice and mechanical performance. <br />Thus, the presented work demonstrates the fabrication of various embroidered single- and bi-component scaffolds made of two commercially available monofilament threads (polydioxanone, poly(lactic acid-co-·- caprolactone)) as well as a novel melt spun poly(L-lactic acid) multifilament and their mechanical analysis by tensile tests and under cyclic loading. <br />Selected scaffolds, adjusted by material composition and textile parameters, revealed a load–strain behavior comparable to native lapin ACL tissue exhibiting a sufficient amount of elastic deformation within the toe-region of 1.7%, scaffold stiffness of 123 N/mm and adequate maximum tensile load (300 N) and strain (20%). Therefore, the design of resorbable embroidered bi-component scaffolds represents a promising approach to replace artificial non-resorbable ligament grafts and allows for innovative tissue engineering strategies.
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Publisher
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Textile Research Journal
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Wikidata
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Citation
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Textile Research Journal 85 (2015) 1431-1444
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DOI
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https://doi.org/10.1177/0040517514566107
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Tags
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embroidery technology mechanical properties acl rabbit structure properties scaffold medical textiles
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