Authors
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Yang, Y. ; Qi, P. ; Ding, Y. ; Maitz, M.F. ; Yang, Z. ; Tu, Q. ; Xiong, K. ; Leng, Y. ; Huang, N.
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Title
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A biocompatible and functional adhesive amine-rich coating based on dopamine polymerization
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Date
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13.10.2014
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Number
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44402
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Abstract
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Amine groups physiologically play an important role in regulating the growth behavior of cells and they have technological advantages for the conjugation of biomolecules. In this work, we present a method to deposit a copolymerized coating of dopamine and hexamethylendiamine (HD) (PDAM/HD) rich in amine groups onto a target substrate. This method only consists of a simple dip-coating step of the substrate in an aqueous solution consisting of dopamine and HD. Using the technique of PDAM/HD coating, a high density of amine groups of about 30 nmol/cm2 was obtained on the target substrate surface. The PDAM/HD coating showed the high cross-linking degree that is robust to resist hydrolysis and swelling. As a vascular stent coating, the PDAM/HD presented good adhesion strength to the substrate and resistance to the deformation behavior of compression and expansion of a stent. Meanwhile, the PDAM/HD coating exhibited good biocompatibility and attenuated tissue response compared with 316L stainless steel (SS). The primary amine groups of the PDAM/HD coating could be used to effectively immobilize biomolecules containing carboxylic groups such as heparin. These dates suggested the promising potential of this PDAM/HD coating for the application in the surface modification of biomedical devices.
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Publisher
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Journal of Materials Chemistry B
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Wikidata
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Citation
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Journal of Materials Chemistry B 3 (2014) 72-81
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DOI
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https://doi.org/10.1039/C4TB01236D
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Tags
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