Authors
|
Avitabile, D. ; Salchert, K. ; Werner, C. ; Capogrossi, M. C. ; Pesce, M.
|
Title
|
Growth induction and low-oxygen apoptosis inhibition of human CD34+ progenitors in collagen gels
|
Date
|
18.01.2013
|
Number
|
34431
|
Abstract
|
Various reports have indicated low survival of injected progenitors into unfavorable environments such as the ischemic myocardium or lower limb tissues. This represents a major bottleneck in stem-cell-based cardiovascular regenerative medicine. Strategies to enhance survival of these cells in recipient tissues have been therefore sought to improve stem cell survival and ensure long-term engraftment. In the present contribution, we show that embedding human cord blood-derived CD34+ cells into a collagen I-based hydrogel containing cytokines is a suitable strategy to promote stem cell proliferation and protect these cells from anoxia-induced apoptosis.
|
Publisher
|
BioMed Research International [Elektronische Ressource]
|
Wikidata
|
|
Citation
|
BioMed Research International [Elektronische Ressource] 2013 (2013) Article ID 542810, 5 pages
|
DOI
|
https://doi.org/2013/542810
|
Tags
|
|