Authors
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Lederer, A. ; Boye, S.
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Title
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Asymmetrical flow field flow fractionation for investigation intermolecular interactions of multifunctional polymers
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Date
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01.12.2011
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Number
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29042
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Abstract
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Asymmetrical flow field flow fractionation (AF4) has great potential for characterizing intermolecular interactions, such as complexation and aggregation, in multifunctional polymers. High molar mass aggregates or polymerdrug complexes are separated with low or no destruction by shear forces. AF4 combined with light scattering detection leads to information on the scaling properties of these species. A particular advantage of this method is the filtering effect of the membrane, which enables quantitative characterization of the complexation. Complexation and encapsulation properties of dendritic materials are important for medical and pharmaceutical development of drug delivery systems.
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Publisher
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LCGC Europe : solutions for separation scientists
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Wikidata
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Citation
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LCGC Europe : solutions for separation scientists 24 (2011) 620-628
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DOI
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http://chromatographyonline.findanalytichem.com/lcgc/article/articleDetail.jsp?id=750624
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