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Authors Zschoche, St. ; Rueda, J.C. ; Binner, M. ; Komber, H. ; Janke, A. ; Arndt, K.-F. ; Lehmann, S. ; Voit, B.
Title Reversibly switchable pH- and thermoresponsive core-shell nanogels based on poly(NiPAAm)-graft-poly(2-carboxyethyl-2-oxazoline)s
Date 24.01.2012
Number 29022
Abstract Amphiphilic graft copolymers with a thermosensitive PNiPAAm backbone and pH-sensitive hydrophilic poly(2-carboxyethyl-2-oxazoline) graft chains are synthesized. In aqueous solution, stable micelle-like aggregates are formed by increasing the temperature in the pH range 4.5–5.5. The micelles are crosslinked by electron-beam irradiation, yielding stable core–shell nanogels of about 100 nm diameter with reversible thermo- and pH-dependent swelling behavior. The temperature sensitivity is provided by a conformational change in the PNiPAAm core, whereas the thickness of the poly(2-carboxyethyl-2- oxazoline) corona depends on pH. The reversible bisensitivity of core-crosslinked nanogels is verified by DLS, while AFM measurements demonstrate the predicted core–shell structures of the aggregates.
Publisher Macromolecular Chemistry and Physics
Wikidata
Citation Macromolecular Chemistry and Physics 213 (2012) 215-226
DOI https://doi.org/10.1002/macp.201100388
Tags crosslinking electron beam irradiation micelles stimuli-sensitive polymers nanoparticles temperature-responsive core block-copolymers drug-delivery graft-copolymers cross-linking polymerization poly(n-isopropylacrylamide) nanoparticles micelles state

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