Authors
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Zschoche, St. ; Rueda, J.C. ; Binner, M. ; Komber, H. ; Janke, A. ; Arndt, K.-F. ; Lehmann, S. ; Voit, B.
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Title
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Reversibly switchable pH- and thermoresponsive core-shell nanogels based on poly(NiPAAm)-graft-poly(2-carboxyethyl-2-oxazoline)s
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Date
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24.01.2012
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Number
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29022
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Abstract
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Amphiphilic graft copolymers with a thermosensitive PNiPAAm backbone and pH-sensitive hydrophilic poly(2-carboxyethyl-2-oxazoline) graft chains are synthesized. In aqueous solution, stable micelle-like aggregates are formed by increasing the temperature in the pH range 4.55.5. The micelles are crosslinked by electron-beam irradiation, yielding stable coreshell nanogels of about 100 nm diameter with reversible thermo- and pH-dependent swelling behavior. The temperature sensitivity is provided by a conformational change in the PNiPAAm core, whereas the thickness of the poly(2-carboxyethyl-2- oxazoline) corona depends on pH. The reversible bisensitivity of core-crosslinked nanogels is verified by DLS, while AFM measurements demonstrate the predicted coreshell structures of the aggregates.
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Publisher
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Macromolecular Chemistry and Physics
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Wikidata
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Citation
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Macromolecular Chemistry and Physics 213 (2012) 215-226
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DOI
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https://doi.org/10.1002/macp.201100388
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Tags
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crosslinking electron beam irradiation micelles stimuli-sensitive polymers nanoparticles temperature-responsive core block-copolymers drug-delivery graft-copolymers cross-linking polymerization poly(n-isopropylacrylamide) nanoparticles micelles state
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