Dr. Toshihisa Osaki
Kanagawa Institute of Industrial Science and Technology, Kanagawa, Japan
Title: "Artificial Cell Membrane Platforms for Drug Discovery and Super Sensors"
June, 28, 2019, 10:30, Seminar Room Max Bergmann Center
Carsten Werner participates in the "Nanolithography of Biointerfaces Faraday Discussion" (03.-05. July 2019) at the Royal Society of Chemistry in London, UK,
presenting our recent progress on charge-tuning of glycosaminoglycan-based hydrogels for cytokine sequestration (co-authors Passant Atallah, Yanuar Limasale and Uwe Freudenberg).
15 million people worldwide suffer a stroke each year. To date, treatment options that reduce the consequential damage after a stroke are limited. A promising new approach targets the repair of the vascular system which entails the regeneration of brain tissue and leads to an amelioration of the corresponding body function. In this study, antibodies against Nogo-A, a growth-inhibiting molecule for nerve fibers as well as vessels, were applied to mice after a stroke. The blood vessels in these mice showed improved regenerative capacity, and they recovered affected motor skills better than those of the mice in the control group. To eliminate the impact of signaling from the surrounding tissue observed in in vivo studies, capillary network formation was furthermore investigated in a three dimensional culture of human umbilical vein vascular endothelial cells (HUVECs) in defined glycosaminglycan-starPEG-based hydrogels confirming the in vivo results. Antibodies against Nogo-A are already being used in a phase II study to treat patients with spinal cord injuries and could soon significantly benefit stroke patients as well.

Press Release Universität Zürich

Ruslan Rust et al. Nogo-A Targeted Therapy Promotes Vascular Repair and Functional Recovery Following Stroke. PNAS. June 24, 2019. DOI: 10.1073/pnas.1905309116
Manfred Maitz (IBP) has been appointed as Guest-Professor (2019-2023)
at the "Southwest Jiaotong University in Chengdu", China.

The German Research Foundation (DFG) will support Alla Synytska (Polymer Interfaces, IPF) and Carsten Werner over the next three years to work on a new project titled „Amphiphilic Fouling-Resistant Surfaces Based on Janus particles”.

Alla Synytska, Jens Friedrichs and team will jointly explore a new, scalable design strategy for amphiphilic surfaces with controlled fouling resistance relying polymer-functionalized colloidal particles as surface-immobilized building blocks. The ability of the developed surfaces to inhibit adhesion of different bacterial species will be tested using high throughput bulk- as well as single cell-assays. The combination of these methods is expected to gain mechanistic insight in the anti-adhesive capabilites of amphiphilic surfaces.

Ralf Zimmermann presents our recent findings on "Spatio-temporal morphogen gradients to direct cell-fate decisions in glycosaminoglycan-based hydrogels" at the "13th International Symposium on Electrokinetics" (12.-14. June 2019) at the Massachusetts Institute of Technology, Cambridge, MA, USA.

ELKIN is a conference series for the discussion of new advances in research on electrokinetic phenomena and related topics. The meeting is held every two years at different locations worldwide (the previous conference took place at the IPF in 2017).

The participants of ELKIN 2019 will commemorate Johannes Lyklema (1930-2017), the founder and long term chairman of the "International Advisory Board" of the conference series, with a dedicated lecture given by Jerome Duval.
Carsten Werner and Uwe Freudenberg have been invited to present at the

"TERMIS European Chapter Meeting 0019 - Tissue Engineering Therapies: From Concept to Clinical Translation & Commercialisation"

(27.-31. May 2019) in Rhodes, Greece.

TERMIS is the most prominent organisation in the field of tissue engineering and regenerative medicine globally.
Carsten Werner will present a keynote
„Glycosaminoglycan-based biohybrid hydrogels to promote healing of chronic skin wounds“

at the "4th NanoBio Surfaces and Interfaces in Healthcare and Science Workshop"

(16.-17. May 2019) in Potsdam, Germany.
Symposium "Personalisierte Medizin - Diagnostik - Medizintechnik"
20.03.2019 | 09.00 - 17.45 Uhr | KARL STORZ Besucher- und Schulungszentrum Berlin
Patienten brauchen einen schnellen Zugang zu neuesten diagnostischen Technologien und individuellen Therapien. Heute - nicht erst in 20 Jahren.
Das Leibniz-Symposium am 20. März 2019 widmet sich deshalb neuen Ansätzen in Medizin und Medizintechnik, die eine frühe und therapiebegleitende Diagnostik ermöglichen und so eine personalisierte Behandlung als Standard in Kliniken und Arztpraxen etablieren können.
Angefangen bei der Behandlung von Krebs und der Rolle, die Biomarker und Bildgebung dabei spielen, über die Diagnostik von Krankheitserregern direkt am Krankenbett bis hin zur Herstellung synthetischer Organe und bioaktiver Materialien im Rahmen der regenerativen Medizin. Mit allem verbunden jedoch: "Big Data" - die Grundvoraussetzung einer modernen Medizin, die frühe und therapiebegleitende Diagnostik und personalisierte Behandlungsansätze als Standard in Kliniken und Arztpraxen etablieren will.
Dr. Linus Stegbauer
Northwestern University, Evanston, USA
Title: "Learning from nature: Investigation of the hybrid nano composites of the chiton tooth towards high-tech 3D-printable materials."
The lab project "Mikrostrukturierung von Polymeroberflächen zur Beeinflussung der Bakterienhaftung" of Richard Wustmann, 11th grade student at Martin-Andersen-Nexö-Gymnasium, Dresden has been awarded 2nd place in area Dresden-Ostsachsen in the Physics category.

Richard Wustmann applied a low pressure plasma-based wrinkling procedure to fabricate laterally graded microstructures on polydimethylsiloxane. These surfaces were used in subsequent screening experiments to explore the impact of micron-scale surface morphology on bacterial adhesion.


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