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Dr. Jens Friedrichs

Institute of Biofunctional Polymer Materials
+49 351 4658 595/ 623 +49 351 4658 533

Personal Data

  • 2005-2009 – PhD at the Biotechnology Center of TU Dresden in the research group of Daniel Müller
  • 2010 – research scientist at the Biotechnology Center of TU Dresden
  • since 2011 – research scientist at Leibniz Institute of Polymer Research Dresden

Fields of Work

  • application of atomic force microscopy (imaging, force spectroscopy) to various fields of research
  • main focus on quantification of mammalian and bacterial cell adhesion using single-cell force spectroscopy (SCFS)
  • development of techniques to increase the throughput of SCFS experiments
  • establishment of an AFM service platform

Publications

  • Arulmozhivarman, G. ; Krater, M. ; Wobus, M. ; Friedrichs, J. ; Bejestani, E. P. ; Müller, K. ; u.a., Zebrafish in-vivo screening for compounds amplifying hematopoietic stem and progenitor cells: - Preclinical validation in human CD34+stem and progenitor cells more Scientific Reports 7 (2017) ID12084
  • Magno, V. ; Friedrichs, J. ; Weber, H. ; Prewitz, M. ; Tsurkan, M. ; Werner, C. Macromolecular crowding for tailoring tissue-derived fibrillated matrices more Acta Biomaterialia 55 (2017) 109-119
  • Binner, M. ; Bray, L. ; Friedrichs, J. ; Tsurkan, M. ; Werner, C. Cell-instructive starPEG-heparin-collagen composite matrices more Acta Biomaterialia 53 (2017) 70-80
  • Kirillova, A. ; Marschelke, C. ; Friedrichs, J. ; Werner, C. ; Synytska, A. Hybrid hairy Janus particles as novel building blocks for antifouling surfaces more ACS Applied Materials & Interfaces 8 (2016) 32591-32603
  • Borg, D. ; Welzel, P. ; Grimmer, M. ; Friedrichs, J. ; Weigelt, M. ; Wilhelm, C. ; Prewitz, M. ; Stißel, A. ; Hommel, A. ; Kurth, T. ; Freudenberg, U. ; Bonifacio, E. ; Werner, C. Macroporous biohybrid cryogels for co-housing pancreatic islets with mesenchymal stromal cells more Acta Biomaterialia 44 (2016) 178-187
  • Zimmermann, R. ; Friedrichs, J. ; Lanfer, B. ; Freudenberg, U. ; Werner, C. Aligned fibrillar collagen matrices more Wiley 1 (2016) Chapter 27, 340-354
  • Helbig, R. ; Günther, D. ; Friedrichs, J. ; Rößler, F. ; Lasagni, A. ; Werner, C. The impact of structure dimensions on initial bacterial adhesion more Biomaterials Science 2016 (2016) 1074-1078
  • Dhawan, A. ; Friedrichs, J. ; Bonin, M. v. ; Bejestani, E. P. ; Werner, C. ; Wobus, M. ; Chavakis, T. ; Bornhäuser, M. Breast cancer cells compete with hematopoietic stem and progenitor cells for intercellular adhesion molecule 1-mediated binding to the bone marrow microenvironment more Carcinogenesis 37 (2016) 759-767
  • Poitz, D. M. ; Ende, G. ; Stütz, B. ; Augstein, A. ; Friedrichs, J. ; Brunnssen, C. ; Werner, C. ; Strasser, R. H. ; Jellinghaus, S. EphrinB2/EphA4-mediated activation of endothelial cells increases monocyte adhesion more Molecular Immunology 68 (2015) 648-656
  • Prewitz, M. ; Stißel, A. ; Friedrichs, J. ; Träber, N. ; Vogler, S. ; Bornhäuser, M. ; Werner, C. Extracellular matrix deposition of bone marrow stroma enhanced by macromolecular crowding more Biomaterials 73 (2015) 60-69
  • Reichert, D. ; Friedrichs, J. ; Ritter, S. ; Käubler, T. ; Werner, C. ; Bornhäuser, M. ; Corbeil, D. Phenotypic, morphological and adhesive differences of human hematopoietic progenitor cells cultured on murine versus human mesenchymal stromal cells more Scientific Reports 5 (2015) Article number: 15680
  • Friedrichs, J. ; Werner, C. Polymeric coatings to fight biofouling more Springer (2015) 1944-1950
  • Amornsudthiwat, P. ; Nitschke, M. ; Zimmermann, R. ; Friedrichs, J. ; Grundke, K. ; Pöschel, K. ; Damrongsakkul, S. ; Werner, C. Comprehensive characterization of well-defined silk fibroin surfaces: Toward multitechnique studies of surface modification effects more Biointerphases 10 (2015) 029501
  • Fischer, M. ; Vahdatzadeh, M. ; Konradi, R. ; Friedrichs, J. ; Maitz, M.F. ; Freudenberg, U. ; Werner, C. Multilayer hydrogel coatings to combine hemocompatibility and antimicrobial activity more Biomaterials 56 (2015) 198-205
  • Bray, L. ; Binner, M. ; Holzheu, A. ; Friedrichs, J. ; Freudenberg, U. ; Hutmacher, D. W. ; Werner, C. Multi-parametric hydrogels support 3D in vitro bioengineered microenvironment models of tumour angiogenesis more Biomaterials 53 (2015) 609-620
  • Ende, G. ; Poitz, D. ; Wiedemann, E. ; Augstein, A. ; Friedrichs, J. ; Giebe, S. ; Weinert, S. ; Werner, C. ; Strasser, R. H. ; Jellinghaus, S. TNF-a-mediated adhesion of monocytes to endothelial cells - The role of ephrinA1 more Journal of Molecular and Cellular Cardiology 77 (2014) 125-135
  • Schubert, R. ; Strohmeyer, N. ; Bharadwaj, M. ; Ramanathan, S. P. ; Krieg, M. ; Friedrichs, J. ; Franz, C. M. ; Müller, D. J. Assay for characterizing the recovery of vertebrate cells for adhesion measurements by single-cell force spectroscopy more FEBS Letters 588 (2014) 3639-3648
  • Markwardt, J. ; Friedrichs, J. ; Werner, C. ; Davids, A. ; Weise, H. ; Lesche, R. ; Weber, A. ; Range, U. ; Meißner, H. ; Lauer, G. ; Reitemeier, B. Experimental study on the behavior of primary fuman osteoblasts on laser-cused pure titanium surfaces more Journal of Biomedical Materials Research Part B: Applied Biomaterials 102 (2014) 1422-1430
  • Welzel, P. ; Friedrichs, J. ; Grimmer, M. ; Vogler, S. ; Freudenberg, U. ; Werner, C. Cryogel micromechanics unraveled by atomic force microscopy-based nanoindentation more Advanced Healthcare Materials 3 (2014) 1849-1853
  • Arnold, G. ; Schade, E. ; Schneider, Y. ; Friedrichs, J. ; Babick, F. ; Werner, C. ; Rohm, H. Influence of individual phospholipids on the physical properties of oil-based suspensions more Journal of the American Oil Chemists' Society 91 (2014) 71-77
  • Ende, G. ; Poitz, D. ; Augstein, A. ; Wiedemann, E. ; Friedrichs, J. ; Werner, C. ; Strasser, R. H. ; Jellinghaus, S. Involvement of ephrinA1 in TNF-alpha-mediated monocyte adhesion more European Heart Journal 34 (2013) P596, 114
  • Poitz, D. ; Stölzel, F. ; Arabanian, L. ; Friedrichs, J. ; Docheva, D. ; Schieker, M. ; Fierro, F. ; Platzbecker, U. ; Ordemann, R. ; Werner, C. ; Bornhäuser, M. ; Strasser, R. H. ; Ehninger, G. ; Illmer, T. MiR-134-mediated b1 integrin expression and function in mesenchymal stem cells more Biochimica et Biophysica Acta : BBA - Molecular cell research 1833 (2013) 3396-3404
  • Teräväinen, T. P. ; Myllymäki, S. M. ; Friedrichs, J. ; Strohmeyer, N. ; Moyano, J. V. ; Wu, C. ; Matlin, K. S. ; Müller, J. ; Manninen, A. aV integrins are required for mechanotransduction in MDCK epithelial cells more PLoS One [Elektronische Ressource] 8 (2013) e71485
  • Prewitz, M. ; Seib, P. ; Bonin, M. v. ; Friedrichs, J. ; Stißel, A. ; Niehage, C. ; Müller, K. ; Anastassiadis, K. ; Waskow, C. ; Hoflack, B. ; Bornhäuser, M. ; Werner, C. Tightly anchored tissue-mimetic matrices as instructive stem cell microenvironments more Nature Methods 10 (2013) 788-794
  • Friedrichs, J. ; Müller, D. J. ; Werner, C. Quantifying cellular adhesion to covalently immobilized extracellular matrix proteins by single-cell force spectroscopy more Humana Press 3rd Editio (2013) 19-37