Authors
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Chen, Y. ; Zhang, X. ; Zhao, S. ; Maitz, M.F. ; Zhang, W. ; Yang, S. ; Mao, J. ; Huang, N. ; Wan, G.
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Title
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In situ incorporation of heparin/bivalirudin into a phytic acid coating on biodegradable magnesium with improved anticorrosion and biocompatible properties
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Date
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03.05.2017
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Number
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53321
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Abstract
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Heparin (Hep) or bivalirudin (BVLD) were immobilized in an organic phytic acid (PA) coating on Mg by an in situ chemical route. Such a drug-loaded PA coating was designed to enhance both corrosion control and biocompatibility. It was found that both Hep- and BVLD-loaded PA coatings exhibited a dual role in effectively controlling corrosion as well as providing a biofunctional effect. Experiments involving electrochemical corrosion and in vitro degradation by immersion revealed that PA&Hep- and PA&BVLD-coated Mg had the same effect or even slower corrosion/degradation in phosphate buffered saline compared to PA-coated Mg, and it degraded significantly slower than untreated Mg. Moreover, Hep- or BVLD-loaded PA coatings showed relatively good hemocompatibility, with a prolonged clotting time, inhibited platelets adhesion as well as reduced hemolysis compared to untreated Mg. In addition, both PA&Hep and PA&BVLD coatings promoted endothelial cells growth and restrained the proliferation of smooth muscle cells. In vivo assays indicated that PA&Hep-coated Mg exhibited a significant difference in mass loss compared to untreated Mg, as well as better histocompatibility than other samples. These results demonstrate that our coating strategy shows a great potential in surface modification of biodegradable Mg. Finally, the mechanism for the incorporation of the drugs into the PA coating is discussed from both theoretical and practical perspectives.
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Publisher
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Journal of Materials Chemistry B
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Wikidata
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Citation
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Journal of Materials Chemistry B 5 (2017) 4162-4176
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DOI
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https://doi.org/10.1039/C6TB03157A
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Tags
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