Title Autotemplate microcapsules of CaCO3/pectin and nonstoichiometric complexes as sustained tetracycline hydrochloride delivery carriers
Date 03.10.2017
Number 53929
Abstract New types of composites were obtained by an autotemplate method for assembling hollow CaCO3 capsules by using pH-sensitive polymers. Five pectin samples, which differ in the methylation degree and/or amide content, and some nonstoichiometric polyelectrolyte complex dispersions, prepared with the pectin samples and poly(allylamine hydrochloride), were used to control the crystal growth. The morphology of the composites was investigated by scanning electron microscopy, and the polymorphs characteristics were investigated by FTIR spectroscopy. The presence of the polymer in the composite particles was evidenced by X-ray photoelectron spectroscopy, particle charge density, and zeta-potential. The new CaCO3/pectin hollow capsules were tested as a possible matrix for a tetracycline hydrochloride carrier. The kinetics of the drug release mechanism was followed using Higuchi and Korsmeyer–Peppas mathematical models.
Publisher ACS Applied Materials & Interfaces
Identifier 0
Citation ACS Applied Materials & Interfaces 9 (2017) 37264-37278
Authors Mihai, M. ; Racovita, S. ; Vasiliu, A.-L. ; Doroftei, F. ; Barbu-Mic, C. ; Schwarz, S. ; Steinbach, C. ; Simon, F.
Tags caco3 microcapsule nonstoichiometric polyelectrolyte complex pectins tetracycline hydrochloride

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