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Dr. Claudia Hinüber

Dept. Processing
+49 351 4658 301 +49 351 4658 362

Claudia Hinüber is working at IPF Research Divison for Polymer Materials within the Department Processing since September 2017.

Fields of Work

Biopolymer Fibers & Biocomposites

Facing the extremely complex biological system of human organism, the requirements for scaffold materials in regenerative medicine are enormous and tremendously challenging. Therefore the demands on scaffolds are well defined: biocompatibility, creation of a 3D-network with desired pore size and interconnectivity for directed cell growth and support of vascularization of the ingrown tissue, certain mechanical, physical and chemical properties and appropriate degradation characteristics with non-toxic residues. Textile implants are fascinating, they exhibit the desired properties and due to their high degree of design options and large surface-area-to-volume ratio provide ideal living conditions for cells.

Resorbable biopolymers, as rather new polymer class, are often limited in its applications due to their brittleness. However, fabricated into fibers by means of melt spinning the remarkable potential of PLA or PHB is evident: silk-like fibers with 20-200% elongation of break can be fabricated and further processed by means of textile processing. The thourough investigation of the above mentioned biopolymers, as fundamental units of textile implants, and the deep understandig of biopolymer-processing-structure-properties correlations are the key issues of our research.

Methods

Materials

  • Degradable biopolymers for regenerative medical therapies: PLA, PCL, PHB
  • Biocomposites with CaCO3

Scope of work

  • Scaffold design based on fibers and textiles (e. g. bone, ligament or nerve regeneration)
  • Fundamental understanding of the process of melt spinning of biopolymers and the resulting properties (e.g. mechanics, resorption, release kinetics, stability to sterilization)

Curriculum Vitae

Mar. 2012 – Sep. 2017       
Dresden University of Technology/ IPF, Dresden, Germany
Tissue Engineering/ Scaffold Design

Nov. 2007 – Feb. 2012
Leibniz Institute of Polymer Research, Dresden, Germany
PhD student                          
Research Divison Biofunctional Polymer Materials at the Max Bergmann Center of Biomaterials,
Thesis: nerve guidance channels based on PHB.

Oct. 2001 – Oct. 2007        
Dresden University of Technology, Dresden, Germany
Major: Material Science;
Specialty: Functional Materials

June 2006 – Dec. 2006     
Fraunhofer USA CCL / Michigan State University, Lansing, MI, USA
Thesis: Surface characterization and in vitro investigations
on diamond-like carbon coated biomedical alloys.

Oct. 2004–March 2005
Fraunhofer IFAM, Bremen, Germany
Research assistant – internship                            
Shaping and functional materials: Preparation and evaluation
of nano suspensions using a wet-milling procedure.