Authors
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Wan, G. ; Lv, Bo ; Jin, G. ; Maitz, M.F. ; Zhou, J. ; Huang, N.
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Title
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Direct correlation of electrochemical behaviors with anti-thrombogenicity of semiconducting titanium oxide films
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Date
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10.01.2014
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Number
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41423
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Abstract
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Biomaterials-associated thrombosis is dependent critically upon electrochemical response of fibrinogen on material surface. The relationship between the response and anti-thrombogenicity of biomaterials is not well-established. Titanium oxide appears to have good anti-thrombogenicity and little is known about its underlying essential chemistry. We correlate their anti-thrombogenicity directly to electrochemical behaviors in fibrinogen containing buffer solution. High degree of inherent n-type doping was noted to contribute the impedance preventing charge transfer from fibrinogen into film (namely its activation) and consequently reduced degree of anti-thrombogenicity. The impedance was the result of high donor carrier density as well as negative flat band potential.
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Publisher
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Journal of Biomaterials Applications
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Wikidata
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Citation
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Journal of Biomaterials Applications 28 (2014) 719-728
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DOI
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https://doi.org/10.1177/0885328213476911
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Tags
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anti-thrombogenicity biomaterials-associated thrombosis blood compatibility interfacial charge transfer electrochemical behavior titanium oxide film
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