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Authors Swiety-Pospiech, A. ; Wojnarowska, Z. ; Pionteck, J. ; Pawlus, S. ; Grzybowski, A. ; Hensel-Bielowka, S. ; Grzybowska, K. ; Szulc, A. ; Paluch, M.
Title High pressure study of protic ionic liquid lidocaine hydrochloride: decoupling, thermodynamic scaling, and role of thermal and density fluctuation in molecular dynamics
Date 03.08.2012
Number 32023
Abstract In this paper, we investigate the effect of pressure on the molecular dynamics of protic ionic liquid lidocaine hydrochloride, a commonly used pharmaceutical, by means of dielectric spectroscopy and pressure-temperature-volume methods. We observed that near Tg the pressure dependence of conductivity relaxation times reveals a peculiar behavior, which can be treated as a manifestation of decoupling between ion migration and structural relaxation times. Moreover, we discuss the validity of thermodynamic scaling in lidocaine HCl. We also employed the temperature-volume Avramov model to determine the value of pressure coefficient of glass transition temperature, dTg/dP|P = 0.1. Finally, we investigate the role of thermal and density fluctuations in controlling of molecular dynamics of the examined compound. © 2012 American Institute of Physics
Publisher Journal of Chemical Physics
Wikidata
Citation Journal of Chemical Physics 136 (2012) 224501
DOI http://link.aip.org/link/doi/10.1063/1.4727885
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