Authors
|
Swiety-Pospiech, A. ; Wojnarowska, Z. ; Pionteck, J. ; Pawlus, S. ; Grzybowski, A. ; Hensel-Bielowka, S. ; Grzybowska, K. ; Szulc, A. ; Paluch, M.
|
Title
|
High pressure study of protic ionic liquid lidocaine hydrochloride: decoupling, thermodynamic scaling, and role of thermal and density fluctuation in molecular dynamics
|
Date
|
03.08.2012
|
Number
|
32023
|
Abstract
|
In this paper, we investigate the effect of pressure on the molecular dynamics of protic ionic liquid lidocaine hydrochloride, a commonly used pharmaceutical, by means of dielectric spectroscopy and pressure-temperature-volume methods. We observed that near Tg the pressure dependence of conductivity relaxation times reveals a peculiar behavior, which can be treated as a manifestation of decoupling between ion migration and structural relaxation times. Moreover, we discuss the validity of thermodynamic scaling in lidocaine HCl. We also employed the temperature-volume Avramov model to determine the value of pressure coefficient of glass transition temperature, dTg/dP|P = 0.1. Finally, we investigate the role of thermal and density fluctuations in controlling of molecular dynamics of the examined compound. © 2012 American Institute of Physics
|
Publisher
|
Journal of Chemical Physics
|
Wikidata
|
|
Citation
|
Journal of Chemical Physics 136 (2012) 224501
|
DOI
|
http://link.aip.org/link/doi/10.1063/1.4727885
|
Tags
|
|