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SAB ''Implant with integrated drug delivery''

Concept

The implant draft was developed in the BMBF-project “novel concept…”. The antibiotics are integrated into the textile structure by incorporating them into a degradable polymer matrix, which is coated on the implants thread surface. There are different approaches for solving this problem. The IPF is assigned to the examination of drug release from degradable polylactid- (PLA) bzw. polylactid-co-glycolid- (PLGA) matrices.

Indication

Complex injuries or fractures, extended surgeries, old and ailing patients as well as the implant materials associate the risk of infections. The incidence of nosocomial infections diminish a successful treatment and often result in a removal of the implant. Systemic administration of antibiotics are applied to reduce the risk of postsurgical infections. Therefore high doses of antibiotics are required to deliver the essential concentration to the lesion. This high doses can affect the hole organism and it is not guaranteed that the minimal inhibitory concentration (MIC) is achieved locally. A local administration of antibiotics in the aftermath of the surgery is seen to be an optimal treatment to prevent nosocomial infections and the formation of biofilms. Therefore the implant material needs to be equipped with a drug delivery system.

Principle

The antibiotics are incorporated in a degradable matrix polymer. The agent is attached to the threads surface by dip-coating the PCL-thread in an antibiotic/polymer-solution.

fig. 1: principle of drug release from polymer matrix
 
SAB ''Implant with integrated drug delivery''
SAB ''Implantate mit integrierter Freisetzung von Wirkstoffen''

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