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Ron Dockhorn

Fields of research

Theory and computer simulation of DNA-segregation in eukaryotes and prokaryotes

  • Simulations of different species, esp. linear or ring polymers, under topological constraints such as cylindrical confinement as a model of prokaryotic DNA during replication
  • Modeling of chromatin segregation during the cell cycle in eukaryotes under the effect of SMC-proteins with the bond fluctuation model
  • Investigations on different models of condensin during the segregation process of sister chromatids and the influence of internal structure
  • Comparison of static and dynamic properties of the resulting structures with mean-field-predictions and scaling theory

Theory, experiments and computer simulation of star-PEG-heparin-polyelectrolyte hydrogels

  • Synthesis and physical characterization of biohybrid hydrogels, esp. swelling degree and storage modulus
  • Simulation of network formation using the bond fluctuation model and characterisation of the resulting structure (defect density, swelling behavior)
  • Comparison of static and dynamic properties, especially swelling behavior, relaxation time with theoretical predictions

 

Miscellaneous

I'm the programmer of the application JBFM for simulating and educational purpose. It implements the bond-fluctuation-model in pure Java and runs on different architectures and operating system and even within a web browser. As default a grafical user interface, live-3D- output, different types of polymers starting configurations and calculation/representation of observables are implemented.

 
Ron Dockhorn
Ron Dockhorn

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