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Ionov, L. ; Stamm, M. ; Diez, S.
Size sorting of protein assemblies using polymeric gradient surfaces

We report on a novel approach for the size-dependent fractionation of protein assemblies on polymeric surfaces. Using a simple temperature gradient method to generate one-dimensional gradients of grafted poly(ethylene glycol), we fabricated silicon-oxide chips with a gradually changing surface density of kinesin motor molecules. We demonstrate that such a bioactive surface can be used to sort gliding microtubules according to their length. To our knowledge, this is the first example of the self-organized sorting of protein assemblies on surfaces.

Quelle
Nano letters 5

Seiten
1910-1914

DOI
http://dx.doi.org/10.1021/nl051235h

Erschienen am
December 2005
 
Publications
Publications

Departments

Nanostructured Materials