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Rubio Retema, J. ; Zafeiropoulos, N.E. ; Serafinelli, C. ; Rojas-Reyna, R. ; Voit, B. ; Lopez-Cabarcos, E. ; Stamm, M.
Synthesis and characterization of thermosensitive PNIPAM microgels covered with superparamagnetic g-Fe2O3 Nanoparticles

In the present study we report a facile and reproducible method of preparing magnetic thermosensitive hybrid material based on P(NIPAM) microgels covered with -Fe2O3 nanoparticles of 6-nm size. The iron oxide nanoparticles provided magnetic response to the microgels. In addition, the presence of the magnetic nanoparticles on the microgels altered their swelling behavior and shifted their volume phase transition temperature to higher values. In particular, for inorganic shells with 18% (w/w) of magnetic nanoparticles the volume phase transition of the microgels was shifted from 36 to 40 C. In contrast, for shells consisting of 38% (w/w) magnetic nanoparticles the volume phase transition of the microgels was almost blocked, thus indicating that the microgel thermal response was strongly affected by the presence of the inorganic nanoparticles. The synthesized thermosensitive magnetic microgels are envisaged to be ideal for potential applications as thermosensitive targeted drug delivery systems.

Source
Langmuir 23

Pages
10280-10285

DOI
http://dx.doi.org/10.1021/la7009594

Published
September 2007
 
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Publications

Departments

Nanostructured Materials