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Pompe, T. ; Zschoche, St. ; Herold, N. ; Salchert, K. ; Gouzy, M.-F. ; Sperling, C. ; Werner, C.
Maleic Anhydride Copolymers - A Versatile Platform for Molecular Biosurface Engineering

A platform of thin polymer coatings was introduced for the functional modulation of immobilized bioactivemolecules at solid/liquid interfaces. The approach is based on covalently attached alternating maleic acidanhydride copolymers with a variety of comonomers and extended through conversion of the anhydridemoieties by hydrolysis, reaction with functional amines, and other conversions of the anhydride moieties.We demonstrate that these options permit control of the physicochemical constraints for bioactive moleculesimmobilized at interfaces to influence important performance characteristics of biofunctionalized materialsfor medical devices and molecular diagnostics. Examples concern the impact of the substrate-anchorage offibronectin on the formation of cell-matrix adhesions, the orientation of endothelial cells according tolateral anti-adhesive micropatterns using grafted poly(ethylene oxide), and the spacer-dependent activity ofimmobilized synthetic thrombin inhibitors.

Source
Biomacromolecules 4, 1072-1079

DOI
http://dx.doi.org/10.1021/bm034071c

Published
July 2003
 
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